Combined NK1 antagonism and serotonin reuptake inhibition: effects on emotional processing in humans

Conclusions:
These results suggest that acute administration of GSK424887 modulated some aspects of emotional processing but these effects were not similar to those seen previously with antidepressant agents. This was the first use of the battery of emotional processing tasks in a Phase 1 study. Repeated administration of the test and active control drugs may be needed to reliably characterise their effects.

Source: Journal of Psychopharmacology - April 19, 2013 Category: Psychiatry Authors: Harmer, C. J., Dawson, G. R., Dourish, C. T., Favaron, E., Parsons, E., Fiore, M., Zucchetto, M., Bifone, A., Poggesi, I., Fernandes, S., Alexander, R. C., Goodwin, G. M. Tags: Original Papers Source Type: research