Experimental Autoimmune Prostatitis Induces Learning-Memory Impairment and Structural Neuroplastic Changes in Mice.

Experimental Autoimmune Prostatitis Induces Learning-Memory Impairment and Structural Neuroplastic Changes in Mice. Cell Mol Neurobiol. 2019 Aug 10;: Authors: Du H, Chen X, Zhang L, Liu Y, Zhan C, Chen J, Wang H, Yu Z, Liang C Abstract Patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) commonly experience learning and memory decline and the underlying pathogenesis remains unclear. Therefore, we aimed to study the effects of CP/CPPS on cognitive function by using a mouse model of experimental autoimmune prostatitis (EAP). Non-obese diabetic mice were immunized subcutaneously by prostate antigen and adjuvant twice and tested for cognitive performance by Morris water maze and novel object recognition test after the EAP induction. Then, dendritic complexity and spine densities were measured by using the Golgi-Cox procedure. Transmission electron microscopy was used to observe the synaptic morphology. In addition, activation of microglia and its association with synapses were also investigated by immunofluorescence staining. Our results showed that EAP induced a notable decrease in the learning and memory ability of mice, simultaneously causing a reduction in dendritic complexity detected by Sholl analysis. Likewise, the spine densities and synaptic proteins including synaptophysin and postsynaptic density protein 95 (PSD95) were significantly decreased in the EAP group. These observations were also accompanied b...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research

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Neck and back pain caused by intervertebral disc (IVD) degeneration is a frequent cause of referral to spine surgeons. This is a multifactorial disease process caused by aging, injury, obesity, and mechanical stress. Recently, an association between IVD degeneration and diabetes has been identified, but the mechanisms underlying this relationship are unclear. Furthermore, the effects of insulin levels on cytokines known to be elevated in diabetics have not previously been delineated. Uncontrolled diabetes results in chronic systemic inflammation with increased circulating levels of IL-6 and IL-18.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research
Staying healthy is best done with expert help. We all need medical care at some point. And if chronic illness strikes, it requires the guidance of someone with the ability to make diagnoses and balance treatments that are often aimed at different organ systems. Primary care physicians (PCPs) are generalists who see adult patients for common ailments including respiratory infections, headaches, back pain, and urinary infections. They also manage chronic conditions such as high blood pressure, diabetes, heart disease, obesity, anxiety, and depression. In addition, PCPs have expertise in managing multiple treatments, medicati...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
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Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
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Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
By PHUOC LE MD Fifteen years ago, as a medical student, I learned a terrifying lesson about blindly using race-based medicine. I was taking care of Mr. Smith, a thin man in his late 60s, who entered the hospital with severe back pain and a fever. As the student on the hospital team, I spent over an hour interviewing him, asking relevant questions about his medical and social history, the medications he took, and the details of his symptoms. I learned Mr. Smith was a veteran who ran into tough times that left him chronically homeless, uninsured, and suffering from hypertension and diabetes. I performed a complete physica...
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