Aspirin may raise death among some breast cancer patients

Using aspirin may raise risk of death in some women with breast cancer, a study says. Researchers say the drug may interact during methylation, a chemical shift in DNA activation, to increase the risk of death.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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Publication date: 1 October 2019Source: Life Sciences, Volume 234Author(s): Mohamed M. Fathy, Heba M. Fahmy, Omnia A. Saad, Wael M. ElshemeyAbstractAimsConventional radiotherapy is mainly restricted by the low radiation absorption efficiency of tumors tissues and the hypoxic tumor cells radio-resistance. In this paper, novel nano-radiosensitizers, magnetic nanoparticles core coated with silica, were successfully prepared to overcome these limitations.Main methodsThe prepared nanoparticles have been characterized by transmission electron microscope (TEM), Dynamic light scattering (DLS), atomic force microscope (AFM) and vib...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 16 August 2019Source: Journal of Photochemistry and Photobiology A: ChemistryAuthor(s): M. Waseem Akram, Fazal Raziq, Muhammad Fakhar-e-Alam, Muhammad Hammad Aziz, K.S. Alimgeer, M. Atif, M. Amir, Atif Hanif, W. Aslam FarooqAbstractAu-TiO2 nanoparticles conjugated with doxorubicin (DOX) were synthesized for new photodynamic therapy (PDT) plans and for comprehensive and reliable treatment of breast cancer-related acute diseases. The anatase/rutile phase junction effect combined with plasmonic resonance is amplified in Au- TiO2 conjugated with DOX, leading to a synergistic response of PDT. ...
Source: Journal of Photochemistry and Photobiology A: Chemistry - Category: Chemistry Source Type: research
AbstractPurpose of ReviewFollowing partial mastectomy, whole-breast irradiation (WBI), delivered over 3 to 6  weeks, has been the standard adjuvant radiation approach for early-stage breast cancer. A growing body of literature over the past decade has suggested that irradiation of the partial breast, including the tumor bed plus a margin, may be a suitable alternative for appropriately selected patients. The use of partial breast irradiation (PBI) has been studied in multiple prospective randomized trials, now with up to 10 years of follow-up, establishing similar safety and efficacy compared with WBI. Advantages...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
AbstractPurpose of ReviewAs medical knowledge and innovation reaches new heights, there is a growing gap in medical advancements between low- and middle-income countries (LMICs) and high-income countries (HICs). The former has lack of basic health care and preventive or diagnostic services for early cancer while the latter has access to novel diagnostic and therapeutic modalities.Recent FindingsKey to overcoming this disparity is finding ways to bridge this divide across distances and continental divides through innovative technology and sharing of knowledge by committed individuals and through public private partnerships....
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
Publication date: Available online 17 August 2019Source: Revista Clínica Española (English Edition)Author(s): J. Masip, J.R. Germà LluchAbstractRecent epidemiological studies have shown that alcohol consumption can increase the risk of arterial hypertension, atrial fibrillation and gastrointestinal and breast cancer. Various sectors are therefore promoting abstinence from alcohol. However, light alcohol consumption has once again been shown to reduce the risk of myocardial infarction and diabetes but with an unclear effect on cerebrovascular disease. The decision to consume alcohol should therefore be ...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
ConclusionIn this study, we found that over-expression of TINCR may influence the tumor size and contribute to the poor prognosis of cancer.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism :This SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Source Type: research
Contributors : Qing-Lan Li ; Dan-Ya Wang ; Lin-Gao Ju ; Chuan Gao ; Pin-Ji Lei ; Lian-Yun Li ; Xiao-Lu Zhao ; Min WuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism :Activation of transcription enhancers, especially super enhancers, is one of the important epigenetic features of tumorigenesis. However, only very few studies reported how the enhancer landscape evolves during tumorigensis. Here we utilized a proteomics approach and found that H3K27ac and H4K8ac are elevated in the mammary tumor of MMTV-PyVT mouse model, which was then confirmed by IHC results in human BRCA chips. ChIP-se...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Source Type: research
Contributors : Qing-Lan Li ; Dan-Ya Wang ; Lin-Gao Ju ; Chuan Gao ; Pin-Ji Lei ; Lian-Yun Li ; Xiao-Lu Zhao ; Min WuSeries Type : Expression profiling by high throughput sequencingOrganism :Activation of transcription enhancers, especially super enhancers, is one of the important epigenetic features of tumorigenesis. However, only very few studies reported how the enhancer landscape evolves during tumorigensis. Here we utilized a proteomics approach and found that H3K27ac and H4K8ac are elevated in the mammary tumor of MMTV-PyVT mouse model, which was then confirmed by IHC results in human BRCA chips. ChIP-seq studies reve...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
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