Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease

Nature Reviews Cardiology, Published online: 12 August 2019; doi:10.1038/s41569-019-0247-5Clonal haematopoiesis of indeterminate potential (CHIP) commonly occurs as a result of mutations in transcriptional regulators and is associated with a doubling of the risk of atherosclerotic cardiovascular disease. Jaiswal and Libby propose that CHIP contributes to the increased inflammation seen in ageing and thereby explains some of the age-related risk of cardiovascular disease.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research