The VirAB-VirSR-AnrAB multi-component system involves in resistance of Listeria monocytogenes EGD-e to cephalosporins, bacitracin, nisin, benzalkonium chloride and ethidium bromide.

This study describes TCS/ABC transporter modules characterized in Listeria monocytogenes EGD-e. It consists of the VirSR TCS and the VirAB and AnrAB ABC transporters. Our results showed that this system is involved in nisin and bacitracin resistance, as well as cephalosporins, ethidium bromide (EtBr) and benzalkonium chloride (BC) resistance. In this system, VirAB is only responsible for antimicrobial sensing and signalling by VirSR, while AnrAB contributes to transport antimicrobial. Interestingly, VirAB itself, instead of the VirAB-VirSR-AnrAB system, contributes to kanamycin and tetracycline resistance. PMID: 31399408 [PubMed - as supplied by publisher]
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research