Antibody Therapy for the Control of Viral Diseases: An Update.

Antibody Therapy for the Control of Viral Diseases: An Update.
Curr Pharm Biotechnol. 2019 Aug 09;:
Authors: Dibo M, Battocchio EC, Dos Santos Souza LM, da Silva MDV, Banin-Hirata BK, Miranda Sapla MM, Marinello P, Rocha SPD, Faccin-Galhardi LC
Abstract
The epidemiological impact of viral diseases combined with the emergence and reemergence of some viruses and the difficulties in identifying effective therapies have encouraged several studies to understand and develop new techniques for the prevention and treatment of viral infections. An example would be the development of immunotherapeutics and their recent application in the treatment and prevenction of viral infections through the use of conventional, bispecific, or multispecific monoclonal antibodies (mAbs). Currently, several immunotherapeutics for the treatment of different viral infections are in the process of being tested, and some are already undergoing clinical trials. Novel methods for obtaining mAbs, such as by using phages, isolating B cells from memory cells, by direct cloning of secretory plasmocytes or of the antibody itself via genetic and molecular coding, are being used. The present work aims to review the action, obtainment and application of monoclonal antibodies in immunotherapy to control viral diseases.
PMID: 31400263 [PubMed - as supplied by publisher]

Source: Current Pharmaceutical Biotechnology - August 8, 2019 Category: Biotechnology Authors: Dibo M, Battocchio EC, Dos Santos Souza LM, da Silva MDV, Banin-Hirata BK, Miranda Sapla MM, Marinello P, Rocha SPD, Faccin-Galhardi LC Tags: Curr Pharm Biotechnol Source Type: research