Conventional formulations, Challenges and Nanomedicines in Infective and Non-Infective Skin Diseases Therapy.

Conventional formulations, Challenges and Nanomedicines in Infective and Non-Infective Skin Diseases Therapy. Recent Pat Antiinfect Drug Discov. 2019 Aug 09;: Authors: Rahman M, Beg S, Akhter S Abstract Oral based formulations for treatment of topical infectious and non-infectious disorders causes numerous adverse reactions including of hepatic toxicity, higher metabolism, poor absorption and serious skin events such as drug - drug interactions resulted from metabolism through the cytochrome P450 system [1-3]. Other prefer routes is topical route, in which drug molecules deliver to the SC or epidermis and retained there for an optimum time to exert it therapeutic effect [3, 4-5]. The skin is an ideal site for drug delivery in treatment of topical infective and non-infective skin disease. But its barrier nature of the skin, diseased condition, physiochemical drug properties are major hurdle for drug delivery [6]. Conventional topical formulations such as creams and ointments have failed to gain achieve controlled drug release and drug targeting for the treatment of topical disorders. For effective anti-infective drug therapies, it must be administering and deliver the required quantity of drug into or through the skin to be fix into the epidermis/dermis via sustained release of drug [7]. But skin retention of the drug molecules is a challenging task to achieve due to restricted permeability through the skin. In this regard, the applic...
Source: Recent Patents on Anti-Infective Drug Discovery - Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research