Preemptive treatment with voriconazole in lung transplant recipients

Neoh CF, Snell GI, Levvey B, Kotsimbos T, Morrissey CO, Slavin MA, Stewart K, Kong DC
Source: The Aspergillus Website - articles - Category: Respiratory Medicine Source Type: news

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Authors: Ceylan B, Yilmaz M, Beköz HS, Ramadan S, Ertan Akan G, Mert A Abstract Invasive aspergillosis is a severe infection that generally involves the lungs. Primary gastrointestinal aspergillosis is the least common form of invasive aspergillosis. A patient aged 65 years developed a febrile neutropenic episode following an autologous stem cell transplant for plasmacytoid variant diffuse large B-cell gastric non-Hodgkin's lymphoma. He had abdominal pain on the second day of the febrile neutropenic episode and ileus occurred on the sixth day. His general condition deteriorated despite broad spectrum antibioti...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Chronic lung allograft dysfunction (CLAD) has been associated with Aspergillus colonization after lung transplantation. We sought to identify the miRNA profile that distinguishes Aspergillus colonization with CLAD from Aspergillus colonization without CLAD in bronchoalveolar lavages (BALs) collected from lung transplant recipients (LTRs).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 49 Source Type: research
Fungal infections are an important cause of mortality and morbidity in lung transplant recipients, and Aspergillus species are the most common cause of infection. Comprehensive consensus guidelines on antifungal prophylaxis against Aspergillus infection in lung transplant recipients has not been established. There are clinical practice variations in Aspergillus prophylaxis, with regards to duration of treatment, choice of agent, and route of administration. Voriconazole is the agent mostly used as Aspergillus prophylaxis.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 268 Source Type: research
Conclusion: Our study has contributed to understand the interaction response of human lung epithelial cells during A. terreus infection. Also, our study may facilitate the identification of inflammatory biomarker against A. terreus.
Source: Current Signal Transduction Therapy - Category: Molecular Biology Source Type: research
Publication date: Available online 30 January 2019Source: Journal of American Association for Pediatric Ophthalmology and StrabismusAuthor(s): Julius T. Oatts, Jefferson J. Doyle, Mary-Magdalene U. Dodd, Iason S. Mantagos, Linda R. DagiAbstractA 16-year-old boy with a history of relapsed acute myeloid leukemia and a right lower lobe lung abscess confirmed to be Aspergillus presented for a baseline eye examination prior to consideration of bone marrow transplantation. He noted double vision in up-and-left gaze, and his examination was consistent with an acquired right-sided Brown syndrome. Magnetic resonance imaging reveale...
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
Conclusions. ISV is widely used in hematological pts with IFI also in diseases other than acute myeloid leukemia and it is overall well tolerated. ORR to ISV is at least comparable with other antifungal agents. A rec/ref underlying hematological disease impacts both on OS and response to ISV, while having an IFI refractory to other antifungal agents including azoles does not seem to compromise the response to ISV, although this promising result should be confirmed in prospective studies and larger groups of patients.DisclosuresBusca: Gilead: Honoraria, Membership on an entity's Board of Directors or advisory committees, Sp...
Source: Blood - Category: Hematology Authors: Tags: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections: Poster III Source Type: research
Conclusion】Our study is a long-term nationwide study of endemics of visceral mycoses among significant immunosuppressive patients. More recently frequent agents were Mucor spp. in leukemia and MDS, and especially Candida spp. with GVHD. Our data provide valuable evidence that antifungal treatment is one of the most important treatments for leukemia and MDS, and SCT.Figure.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 904. Outcomes Research-Malignant Conditions: Poster II Source Type: research
Conclusion - Results from this retrospective analysis from a single centre showed the lesser incidence of IFI after posaconazole prophylaxis derived from a small sample size within 30 days of AlloSCT. Therefore, we may conclude that posaconazole prophylaxis may serve as an antifungal prophylactic choice for alloSCT recipients without prior fungal infection. Incidence of breakthrough IFI reported here are similar to that reported in comparative studies of fluconazole and posaconazole prophylaxis in alloSCT recipients.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities Source Type: research
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Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
We report a case of Paragonimus westermani infection simultaneously affecting two separate organs that presented as both a pulmonary cavity and adrenal mass in an immunocompromised host.A 65-year-old male with a previous kidney transplant visited our clinic because of hemoptysis. Forty-three months earlier, bilateral spontaneous pneumothorax was diagnosed and treated with oxygen supplementation and right chest tube insertion. At that time, there was no demonstrable cavitary lesion in either lung and no mass in the adrenal glands (Fig. 1A, 1B). Computed tomography (CT) of the chest when the patient presented with hemoptysis...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
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