Sodium Divalproate in Low Doses for Migraine Prevention Sodium Divalproate in Low Doses for Migraine Prevention
Daily sodium divalproate is an effective migraine preventative, but it can have undesirable side effects, such as weight gain. Is a lower, alternate-day dose more tolerable and equally effective?Headache
Publication date: 24 August 2019Source: New Scientist, Volume 243, Issue 3244Author(s): Alice KleinThe body seems to adapt to a low-carb regime in a way that curbs the condition
We present a series of four adult sickle-cell patients who developed PRES. The association of hypertension, renal failure, and immunosuppressants in sickle cell patients may play a role in the development of PRES in this patient population. It is unclear if SC patients have a higher frequency of PRES predisposing factors than the general population or if SC is an independent risk factor for PRES. Despite this limitation, the presence of acute neurological status changes in adult SC patients should trigger suspicion for PRES as management and outcome may be altered.
Publication date: Available online 22 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yu Chiang, Hung-Jung Wang, Cheng-Yu ChenAbstractLeukoencephalopathy, cerebral calcifications, and cysts (LCC) is an extremely rare neurological disease, also known as Labrune syndrome. The disease more commonly affects children and young adults and the characteristic triple imaging findings are leukoencephalopathy, calcifications and multiple cysts, presenting with a variety of supra- and infratentorial symptoms but lacking for extra-neurological manifestations. Coats plus syndrome and cerebroretinal microangiopathy with cal...
ConclusionsThis study evaluated the efficacy characteristics of seven kinds of triptans and their different dosage forms. The present findings provide necessary quantitative information for migraine medication guidelines.
The trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes all marked by unilateral headache and ipsilateral cranial autonomic features. The TACs include cluster headache, paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing, and hemicrania continua. Pathophysiology includes the trigeminal pain system, autonomic system, hypothalamus, and more recently an identified role for the vagus nerve. Diagnosis is made after looking at headache frequency, duration, and accompanying symptoms. Each TAC has its own unique treatment, which is discussed in depth.
CONCLUSION: Patients with IBS in Germany are likely not receiving sufficient diag- nostic evaluation in conformity with the relevant guidelines. The high prevalence of comorbid mental disorders and other pain syndromes implies that the complaints of patients with IBS need to be more comprehensively evaluated and treated. PMID: 31431234 [PubMed - in process]
In conclusion, PACAP27 induced headache and dilated extracerebral arteries (>5 h) and slightly constricted MCA in healthy volunteers. Post hoc analysis of PACAP38 data compared with PACAP27 showed that PACAP isoforms dilates MMA with significantly different magnitude.
Sagittal imbalance in the cervical spine is a major cause of neck pain, headache, fatigue, and disability. While parameters such as C2-C7 lordosis and C2-C7 sagittal vertical axis have been extensively studied, they do not fully characterize cervical sagittal balance. T1 is an important new parameter of both cervical as well as global spinal sagittal balance. However, the T1 superior end plate can be difficult to visualize on standard lateral radiographs due to overlying anatomical structures. C7 slope has therefore been proposed as a potential substitute for T1 slope when the T1 superior end plate is not well visualized.
Publication date: 24–30 August 2019Source: The Lancet, Volume 394, Issue 10199Author(s): The Lancet
Dr Neil Long Funtabulously Frivolous Friday Five 291 It's Friday. Boggle your brain with FFFF challenge and some old fashioned trivia. Funtabulously Frivolous Friday Five 291