Phase 3 Study of Lasmiditan for Acute Treatment Of Migraine Phase 3 Study of Lasmiditan for Acute Treatment Of Migraine

This phase 3 study evaluated the safety and efficacy of lasmiditan, a highly selective and potent 5-HT1F receptor agonist, as a novel therapy for acute migraine.Brain
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

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CONCLUSION: Patients with IBS in Germany are likely not receiving sufficient diag- nostic evaluation in conformity with the relevant guidelines. The high prevalence of comorbid mental disorders and other pain syndromes implies that the complaints of patients with IBS need to be more comprehensively evaluated and treated. PMID: 31431234 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
In conclusion, PACAP27 induced headache and dilated extracerebral arteries (>5 h) and slightly constricted MCA in healthy volunteers. Post hoc analysis of PACAP38 data compared with PACAP27 showed that PACAP isoforms dilates MMA with significantly different magnitude.
Source: Peptides - Category: Biochemistry Source Type: research
Sagittal imbalance in the cervical spine is a major cause of neck pain, headache, fatigue, and disability. While parameters such as C2-C7 lordosis and C2-C7 sagittal vertical axis have been extensively studied, they do not fully characterize cervical sagittal balance. T1 is an important new parameter of both cervical as well as global spinal sagittal balance. However, the T1 superior end plate can be difficult to visualize on standard lateral radiographs due to overlying anatomical structures. C7 slope has therefore been proposed as a potential substitute for T1 slope when the T1 superior end plate is not well visualized.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research
Publication date: 24–30 August 2019Source: The Lancet, Volume 394, Issue 10199Author(s): The Lancet
Source: The Lancet - Category: General Medicine Source Type: research
Dr Neil Long Funtabulously Frivolous Friday Five 291 It's Friday. Boggle your brain with FFFF challenge and some old fashioned trivia. Funtabulously Frivolous Friday Five 291
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: FFFF chest pain David Rytand DHE dihydroergotamine headache Henri Huchard JB Murphy migraine precordial catch Raskin protocol Rytand Law Rytand murmur Surgery Texidor texidor twinge video games Source Type: blogs
This article reviews the published criteria and proposes a new set of criteria. The epidemiology, pathophysiology and management options are also reviewed.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research
Headache is the third leading cause of referral to pediatric emergency departments (ED). Based on a systematic review, headaches in children evaluated in the ED are primarily due to benign conditions that tend to be self-limiting or resolve with appropriate pharmacological treatment. The causes of non-traumatic headache in the ED include more frequently primitive headaches (21.8-66.3%) and benign secondary headaches (35.4-63.2%), whereas potentially life-threatening (LT) secondary headaches are less frequent (2 to 15.3%). Worrying conditions include brain tumors, central nervous system infections, dysfunction of ventricu...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
DiscussionA major strength of this study is its pragmatic nature, where the active treatment group receives chiropractic manipulation according to their individual needs, while both groups continue their use of medication for headache according to their pre-trial habits. Other strengths include an elaborate sham procedure and the weekly outcome reports, reducing recall bias.If it is possible to develop effective treatment for headache in children, a life course of recurring problems may be altered with potential positive implications for both individuals and society.Trial, identifierNCT02684916.
Source: Chiropractic and Manual Therapies - Category: Complementary Medicine Source Type: research
Publication date: Available online 21 August 2019Source: Neurochemistry InternationalAuthor(s): Jingxi Ma, Peifeng Qiao, Qin Li, Yangyang Wang, Lan Zhang, Liang-Jun Yan, Zhiyou CaiAbstractThe Food and Drug Administration has approved vagus-nerve stimulation (VNS) for the treatment of patients with epilepsy, depression, and headache. By targeting diverse neuroprotective and neuroplasticity pathways, VNS has the potential to be expanded as a treatment for ischemic stroke. VNS has been found to attenuate infarct volume, reduce neurological deficits, and improve memory and cognition in rats with stroke injuries. Some pilot stu...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Acupressure is a form of complementary or alternative medicine. Read about research on the efficacy of acupressure for headache, and learn some simple acupressure techniques to try at home.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Headache / Migraine Source Type: news
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