A practical 16-day Desensitization Protocol in Lenalidomide induced Non-immediate Hypersensitivity Reactions.
CONCLUSION: The 16-day desensitization protocol seemed to be safe and effective in the non-immediate type DHRs caused by lenalidomide. PMID: 31400463 [PubMed - as supplied by publisher]
Idiopathic anaphylaxis (IA) is a rare condition that can be lethal.1 Prophylactic regimens for frequent attacks are not yet standardized. These treatments may include long-term systemic corticosteroids, high-dose antihistamines, and mast cell stabilizers. Despite these regimens, patients may become corticosteroid dependent (20%) and develop potential adverse effects.2 Omalizumab is a monoclonal anti-IgE antibody that is indicated in uncontrolled, moderate to severe, persistent asthma3 and chronic idiopathic urticaria.
CONCLUSIONS: The rate of anaphylaxis in patients with ColdU in a tropical country was lower than those reported by other studies conducted intemperate climates. On the other hand, the number of female patients, mean age at symptom onset, atopy rate, rate of concomitant chronic spontaneous urticaria and mean CTT were higher. PMID: 31172722 [PubMed]
AbstractThis review article aims to outline what is known in the pathophysiology of chronic rhinosinusitis with nasal polyposis (CRSwNP) and describe the mechanism of the biologic agents being investigated for this disease. Chronic rhinosinusitis with nasal polyposis is an inflammatory disease of the nasal and paranasal mucosa, which causes symptoms of nasal obstruction, hyposmia, and rhinorrhea. Conventional therapy for CRSwNP includes intranasal corticosteroids (INCS) and polypectomy, but INCS offer only modest benefits, and recurrence after surgery is common. Therefore, effective pharmacologic therapies for CRSwNP are b...
Shanshan Zhang1, Dongli Yuan2 and Ge Tan1* 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2The Institute of Medical Information, Chongqing Medical University, Chongqing, China Primary systemic vasculitis can affect every structure in both the central and peripheral nervous system, causing varied neurological manifestations of neurological dysfunction. Early recognition of the underlying causes of the neurological symptoms can facilitate timely treatment and improve the prognosis. This review highlights the clinical manifestations of primary systemic vasc...
Conclusions: In the CAR registry, patients with SAA treated with omalizumab showed a significant positive effect of anti-IgE therapy not only on the asthma control, but also on allergic comorbidities. PMID: 30429711 [PubMed]
A 5-year-old girl is seen for asthma and food allergies to peanut and tree nuts. Since her last visit, she had one allergic reaction during which she developed hives and wheezing after taking a bite of a muffin cross-contaminated with peanut. This incident was treated with epinephrine. This past winter, she had multiple upper respiratory tract infections that required 2 courses of oral corticosteroids. Her asthma is currently well controlled with daily inhaled fluticasone, with no nighttime awakenings.
CONCLUSIONS: This study provides detailed information that facilitates studying CRS and its main phenotypes. However, patient distribution of this study does not necessarily reflect disease distribution in the general population. PMID: 29911211 [PubMed - as supplied by publisher]
refers to sudden, potentially life-threatening episodes of subcutaneous and/or submucosal swelling. It may be related to allergic diseases and urticaria through the release of mast cell mediators. Bradykinin-mediated angioedema (BK-AE), which is rather uncommon, does not typically respond to epinephrine, antihistamines, or corticosteroids, and obstruction of upper airways or involvement of the gastrointestinal tract may lead to life-threatening situations. BK-AE is usually caused by C1 inhibitor (C1Inh) deficiency, which is hereditary with variants in the SERPING1 gene (types I and II; OMIM 106100) or acquired.
CONCLUSION: CD is a common inflammatory skin disease and should be suspected in patients presenting acute, subacute or chronic dermatitis. The gold standard for diagnosing allergic CD is PT. This article provides practical recommendations for the diagnosis and management of CD commonly seen by the allergist in their practice. PMID: 29522811 [PubMed - as supplied by publisher]
Conclusions: Patients with severe asthma treated with omalizumab showed positive effect of anti-IgE therapy not only on the clinical symptoms of asthma, but also on other allergic comorbidities. Most patients with allergic rhinitis, atopic dermatitis, chronic urticaria and food allergy experienced either improvement or complete remission of symptoms of these diseases.