The Damaging Effect Of Cholesterol On The Brain And On Blood Vessels

Researchers at the Linda Crnic Institute for Down Syndrome and the University of Colorado School of Medicine have found that a single mechanism may underlie the damaging effect of cholesterol on the brain and on blood vessels. High levels of blood cholesterol increase the risk of both Alzheimer's disease and heart disease, but it has been unclear exactly how cholesterol damages the brain to promote Alzheimer's disease and blood vessels to promote atherosclerosis...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cholesterol Source Type: news

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Publication date: 1 January 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 185Author(s): Yenisleidy de las Mercedes Zulueta Díaz, Karen Menghi, Maria Laura Guerrero, Natalia Nocelli, María Laura FananiAbstractL-ascorbic acid alkyl esters (ASCn) are lipophilic forms of vitamin C, which act as skin permeation enhancers. We investigated the physical changes induced by incorporating ASCn into stratum corneum (SC) lipid membranes and correlated this with the mechanism proposed in the literature for skin permeation enhancement phenomena. We used lipid monolayers to explore the 2D structure and elasticit...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01679A, PaperKyu Shik Eom, Yijae Lee, Hye Won Seo, Ji Yoon Kang, Joon S. Shim, Soo Hyun Lee An excessive cholesterol level can lead to cardiovascular diseases, such as stroke, hypertension, and myocardial infarction. A non-invasive, painless method of determining the cholesterol in the blood would improve the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
pirat Chaikuad Conrad Kunick Since hyperactivity of the protein kinase DYRK1A is linked to several neurodegenerative disorders, DYRK1A inhibitors have been suggested as potential therapeutics for Down syndrome and Alzheimer’s disease. Most published inhibitors to date suffer from low selectivity against related kinases or from unfavorable physicochemical properties. In order to identify DYRK1A inhibitors with improved properties, a series of new chemicals based on [b]-annulated halogenated indoles were designed, synthesized, and evaluated for biological activity. Analysis of crystal structures revealed a ty...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ConclusionsIn this high-risk low-income cohort, contributions of risk factors to HF varied, particularly by race. To reduce the population burden of HF, interventions tailored for specific race and sex groups may be warranted.Graphical abstract
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
This study aimed to investigate the association between perceived neighborhood characteristics and subclinical atherosclerosis in a large sample of adults, using cross-sectional data from the ELSA-Brasil (Brazilian Longitudinal Study of Adult Health).MethodsParticipants free of clinical coronary artery disease answered a questionnaire designed to assess their perceptions regarding 6 neighborhood dimensions: social cohesion, walkability, availability of healthy food, safety, witnessed violence, and personal victimization. The scores of each domain were used as independent variables. Common carotid intima-media thickness (CC...
Source: Global Heart - Category: Cardiology Source Type: research
Publication date: Available online 11 November 2019Source: Canadian Journal of CardiologyAuthor(s): Alexander C. Egbe, Keerthana Banala, Rahul Vojjini, Maria Najam, Fouad Khalil, Karim Osman, Mohamed Badawy, Jason H. Anderson, Nathaniel W. TaggartAbstractBackgroundElevated pulmonary artery wedge pressure (PAWP) is the hallmark of left heart failure, and is responsible for heart failure symptoms and mortality. Although, PAWP typically correlates with right atrial pressure (RAP), it is primarily dependent on left heart myocardial properties and volume status. Since right heart disease can occur in the absence of left heart d...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Edward B. Lee, MD, PhDFrom time to time on Neuropathology Blog, we profile a prominent neuropathologist. In the past, we've featured the likes of Craig Horbinski, Roger McLendon,Jan Leestma,Karra Jones,Areli Cuevas-Ocampo,Michael Punsoni,andPJ Cimino, among others. Today we feature Eddie Lee, MD, PhD. Dr. Lee is an assistant professor in the pathology department at the University of Pennsylvania. Here's a Q&A with the illustrious Dr. Lee:1. Why did you decide to become a neuropathologist?The three major topics that dominate Alzheimer ’s disease research are amyloid, tau, and neuroinflammation.&nbs...
Source: neuropathology blog - Category: Radiology Tags: neuropathologists Source Type: blogs
BEST supplements for cholesterol: Having high cholesterol is a ticking time bomb due to it ’s major risk of potentially fatal complications. Thankfully, there are supplements one can take to help reduce their cholesterol levels and as such reduce their risk of serious medical conditions. What are the best supplements to take to help lower cholesterol?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Keeping blood pressure in check may lower the risk of Alzheimer ’s disease and other forms of dementia.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Alzheimer ' s Disease Blood Pressure Dementia Source Type: news
This study measured stimulus-evoked brain tissue oxygenation changes in a mouse model of Alzheimer disease (AD) and further explored the influence of exercise and angiotensin II-induced hypertension on these changes. In vivo two-photon phosphorescence lifetime microscopy was used to investigate local changes in brain tissue oxygenation following whisker stimulation. During rest periods, PO2 values close to the arteriolar wall were lower in the AD groups and the PO2 spatial decay as a function of distance to arteriole was increased by hypertension. During stimulation, tissue PO2 response had a similar spatial dependence acr...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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