Endothelin-1, cardiac morphology, and heart failure: The MESA Angiogenesis Study

Circulating levels of endothelin-1 (ET1) are elevated in heart failure and predict poor prognosis; however, it is not clear whether ET1 elevation is an adaptive response, maladaptive response, or an epiphenomenon of heart failure. In the current study, we evaluated relationships between ET1, cardiac morphology, and incident heart failure or cardiovascular death in participants with no evidence of clinical cardiovascular disease at the time ET1 was measured.

Source: The Journal of Heart and Lung Transplantation - August 9, 2019 Category: Transplant Surgery Authors: Peter J. Leary, Nancy S. Jenny, David A. Bluemke, Steven M. Kawut, Richard A. Kronmal, Joao A. Lima, Bradley A. Maron, David D. Ralph, Samuel G. Rayner, John J. Ryan, Zachary L. Steinberg, Karen D. Hinckley Stukovsky, Ryan J. Tedford Tags: Original Clinical Science Source Type: research