Transgenic mice expressing human IL-32 develop adipokine profiles resembling those of obesity-induced metabolic changes.

In conclusion, our study provides novel evidence of a direct contribution of IL-32 to pathophysiological perturbations within the adipose tissue, possibly contributing to the metabolic syndrome that precedes frank insulin resistance and T2D. Future research should focus on the role of IL-32 in the obesity epidemic.
PMID: 31398626 [PubMed - as supplied by publisher]

Source: Cytokine - August 5, 2019 Category: Molecular Biology Authors: Damen MSMA, Ballak D, Sapinsley Z, Bai X, Chan ED, Seals DR, Popa CD, Joosten LAB Tags: Cytokine Source Type: research