'Lab-grown' rat kidney successfully transplanted

Conclusion This early stage research has developed a new way of growing a bioengineered rat kidney in the laboratory that can produce urine when implanted into a living rat. The researchers have also shown that at least the first stage of this process (removing the cells from a donor kidney) can be achieved with a human kidney. Due to limited availability of donor kidneys for people with kidney disease, researchers and doctors would like to be able to grow human kidneys in the laboratory. This research could be an early step towards developing a potential method for ‘growing’ kidneys in the laboratory that could be used in humans. However, as the authors themselves acknowledge, many hurdles remain. For example, although the bioengineered rat kidneys did filter blood and produce urine, there were signs that these new kidneys were not functioning exactly as a normal adult rat kidney would. This suggested that the kidneys might need longer to mature in the laboratory before transplant, or to be grown in different conditions. If this research is to be extended to humans, the researchers will need to determine an appropriate source of the right kind of human cells and kidney scaffolds for developing human bioengineered kidneys. The current study successfully produced human and pig kidney scaffolds, however, as with transplantable functioning donor kidneys, human kidneys suitable for use as scaffolds may not be easy to obtain. One of the researchers has been reporte...
Source: NHS News Feed - Category: Consumer Health News Tags: Medical practice Source Type: news

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Conclusions Our analysis does not confirm previously reported associations between traffic-related air pollution exposure and the risk of transplant failure.
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsIn this study, we found that circulating complement-activating anti-HLA DSAs had a significant deleterious impact on solid organ transplant survival and risk of rejection. The detection of complement-activating anti-HLA DSAs may add value at an individual patient level for noninvasive biomarker-guided risk stratification. Trial registrationNational Clinical Trial protocol ID: NCT03438058.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Abstract Human BK polyomavirus (BKV) infection is poorly documented in heart and lung transplant patients. BK viruria and viremia have been estimated to affect 19% and 5% of heart transplant recipients, respectively. Data are limited, especially for lung transplantation, but the proportion of patients progressing from BK viruria to viremia or BKV-related nephropathy (BKVN) appears lower than in kidney transplantation. Nevertheless, a number of cases of BKVN have been reported in heart and lung transplant patients, typically with late diagnosis and generally poor outcomes. Risk factors for BKV infection or BKVN in ...
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
Conclusions: In intervention development directed at increasing the level of PA and reducing sedentary time in recipients of solid-organ transplantation, attention should be paid to physical limitations, fear of negative effects, low expectations and self-confidence, health and physical outcomes, and exercise self-efficacy. PMID: 29757444 [PubMed - as supplied by publisher]
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: Phys Ther Source Type: research
​BY ANDRZEJ KIELTYKA, PA; PARDEEP THANDI, MD; &ANUMEHA SINGH, MDA 56-year-old man presented to the emergency department with shortness of breath for one month and pleural effusions on an outpatient chest x-ray. He had been taking adalimumab, methotrexate, and steroids for arthritis and Sjogren's syndrome.A right pleural effusion in a patient with nephrotic syndrome.His monoclonal gammopathy of undetermined significance (MGUS) was monitored annually, but no medical intervention beyond surveillance was required. He had excessive thirst but normal urine output. He noted face and hand swelling in the morning that gave wa...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Authors: Oka M, Miyabe Y, Sugiura N, Nitta K Abstract Treatment using the cell sheet technology has been applied to various organs, including the cornea, heart, esophagus, periodontium, cartilage, middle ear, and lungs. It has been shown that the therapeutic efficacy of cell sheet transplantation involves 2 aspects, supplementation of cells and provision of cytokines to the affected organ. In addition, cell sheet transplantation also promotes repair of damage through the paracrine effects of cytokines derived from the transplanted cells. It is known that in cases of cell transplantation by injection, the transplant...
Source: Contributions to Nephrology - Category: Urology & Nephrology Tags: Contrib Nephrol Source Type: research
This article details the role of neuropsychology in a large transplant center, outlining the requisite training and skills needed to serve these patient populations. While transplant is restricted to major medical centers, patients with end stage organ failure are plentiful and can benefit from neuropsychological expertise, providing a substantial source of clinical expansion and research study for our profession. PMID: 29718077 [PubMed - in process]
Source: Archives of Clinical Neuropsychology - Category: Psychiatry & Psychology Authors: Tags: Arch Clin Neuropsychol Source Type: research
By Maged SrourROME, Apr 30 2018 (IPS)Organ transplantation is one of the most incredible medical achievements of the past century. Since the first successful transplants, which took place in the 1950s, organ transplantation has saved the lives of hundreds of thousands of people worldwide. Dr. Francis Delmonico, is a transplant surgeon with a long career, serving also as an Adviser to the World Health Organization (WHO). Credit: Harvard Health Policy ReviewGlobally about 125,000 people undergo organ transplantation each year. This number is small in the face of demand for organs widely outstripping supply and consequently c...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Crime & Justice Featured Global Headlines Health Human Rights TerraViva United Nations Women's Health Source Type: news
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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