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'Lab-grown' rat kidney successfully transplanted

Conclusion This early stage research has developed a new way of growing a bioengineered rat kidney in the laboratory that can produce urine when implanted into a living rat. The researchers have also shown that at least the first stage of this process (removing the cells from a donor kidney) can be achieved with a human kidney. Due to limited availability of donor kidneys for people with kidney disease, researchers and doctors would like to be able to grow human kidneys in the laboratory. This research could be an early step towards developing a potential method for ‘growing’ kidneys in the laboratory that could be used in humans. However, as the authors themselves acknowledge, many hurdles remain. For example, although the bioengineered rat kidneys did filter blood and produce urine, there were signs that these new kidneys were not functioning exactly as a normal adult rat kidney would. This suggested that the kidneys might need longer to mature in the laboratory before transplant, or to be grown in different conditions. If this research is to be extended to humans, the researchers will need to determine an appropriate source of the right kind of human cells and kidney scaffolds for developing human bioengineered kidneys. The current study successfully produced human and pig kidney scaffolds, however, as with transplantable functioning donor kidneys, human kidneys suitable for use as scaffolds may not be easy to obtain. One of the researchers has been reporte...
Source: NHS News Feed - Category: Consumer Health News Tags: Medical practice Source Type: news

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The week of April 23-27 has been designated as National Pediatric Transplant Week.  This week is to bring attention to the great need for organ donations and to honor  donors and their families whose incredibly selfless gift has given someone the gift of life.While most of us will never experience the need for a transplant, there are many of us who know someone who has a debilitating condition such as kidney dialysis that are in need of a transplant.Right now there are almost 2,000 children on the national transplant list.  Those needing hearts, lungs, eyes, tissue, liver, kidney, or some other body part are...
Source: Pediatric Health Associates - Category: Pediatrics Tags: Volunteer Opportunities Source Type: news
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Renal ischemia-reperfusion injury (IRI) is an inherent process to kidney transplantation. The subsequent release of pro-inflammatory cytokines (e.g., IL-1 β, TNF-α, IL-6) may induce a systemic inflammatory response, resulting in pro-inflammatory cells recruitment and remote organ damage. Several studies have already documented dysfunction of the lung, heart, liver, and brain following renal IRI. The heme oxygenase-1 (HO-1), a stress-responsive enzym e endowed with cytoprotective, antiapoptotic, and immunomodulatory properties, protects kidney from renal IRI when pharmacology induced before ischemia.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Transplantation & Vascular Surgery: Renal Transplantation Vascular Surgery I Source Type: research
Transplant candidates have advanced chronic disease, which often leads to muscular and respiratory impairment contributing to reduced quality of life and daily life activities, and these patients are therefore referred to physiotherapy service. Because of this, it is necessary to know the epidemiologic and functional profile for a better physiotherapeutic approach. Inpatients of kidney, liver, heart, lung and multivisceral transplantation programs were followed up for 1 year. A comparative analysis between groups was performed, taking into account hospital stay time and functional independence measure (FIM).
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Tags: 15th Brazilian Transplantation Congress and 16th Portuguese-Brazilian Transplantation Congress Source Type: research
We have achieved tolerance of cardiac allografts in cynomolgus monkeys for the first time by using a mixed chimerism-based conditioning protocol and by co-transplanting a donor kidney. The mechanism by which a kidney confers tolerance upon a heart is unclear. To gain mechanistic insight and at the same time develop a clinically relevant tolerance protocol, we investigated whether a vascularized donor thymus could substitute for the donor kidney.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Lowering calcineurin inhibitor (CNI) exposure to avoid toxicity is desirable after solid organ transplantation although the risk of organ rejection is of concern after lung transplantation (LTx). The 4Everlung trial was designed to evaluate the benefit of early everolimus (EVR)-based quadruple low immunosuppressive (IS) regimen on kidney function (RF) after LTx
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
We previously developed a molecular diagnostic system for heart transplant biopsies, based on expression of rejection-associated transcripts derived in kidney transplants (J Heart Lung Transplant 36:1192, 2017). We now expanded this to 889 biopsies and examined the relationship to histology in 768 with histology assessments.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
There is growing interest about the long-term lack of pulsatility during continuous flow left ventricular assist device (CFLVAD) on the renal function. Aim of this study is to evaluate the association between renal function and blood pressure during CFLVAD support.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Improved renal function following ventricular assist device (VAD) placement is seen in some, but not all VAD recipients. Failure to improve may indicate enduring renal injury. We hypothesized that VAD implantation results in improved renal function in the majority of pediatric patients with heart failure and that failure to improve would predict poor renal outcomes after heart transplantation (HT).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
There is limited data to guide dual organ allocation in pts implanted with left ventricular assist device with bridge to transplant intention with chronic kidney disease (CKD). The goal of our study was to determine survival outcomes post transplant in LVAD patients with CKD who either received heart transplant alone (HTA) or heart kidney transplant( HKTx).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
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