Detrimental Effects of Chemotherapy on Human Coronary Microvascular Function.

CONCLUSIONS: In vessels from adult subjects, acute treatment with Dox in clinically relevant doses caused significant impairment of coronary arteriolar function, whereas vessels from pediatric subjects showed only marginal impairment to the same stressor. This interesting finding might explain the delayed onset of future adverse CV events in children compared to adults after anthracycline therapy.
PMID: 31397169 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Heart and Circulatory Physiology - August 8, 2019 Category: Physiology Authors: Hader SN, Zinkevich NS, Norwood Toro LE, Kriegel AJ, Kong A, Freed JK, Gutterman DD, Beyer AM Tags: Am J Physiol Heart Circ Physiol Source Type: research