Hyperphosphatemia is Required for Initiation, but not Propagation, of Kidney Failure-Induced Calcific Aortic Valve Disease.

Hyperphosphatemia is Required for Initiation, but not Propagation, of Kidney Failure-Induced Calcific Aortic Valve Disease. Am J Physiol Heart Circ Physiol. 2019 Aug 09;: Authors: Shuvy M, Abedat S, Eliaz R, Abu-Rmeileh I, Abu-Snieneh A, Ben Dov IZ, Meir K, Pereg D, Beeri R, Lotan C Abstract High serum levels of phosphate are associated with uraemia-induced calcific aortic valve disease (CAVD). However, it is not clear whether hyperphosphataemia is required in all phases of the process. Our aim was to determine the effects of phosphate and phosphate depletion at different phases of valve disease. The experimental design consisted of administering a uraemia-inducing diet, with or without phosphate enrichment, to rats for 7 weeks. Forty-two rats were fed with a phosphate-enriched uraemic regimen that caused renal insufficiency and hyperphosphataemia. Another 42 rats were fed with a phosphate-depleted uraemic regimen, which induces similar severity of renal insufficiency, but without its related mineral disorder. Aortic valves were evaluated at several points during the time of diet administration. In the second part, 54 rats were fed a phosphate-enriched diet for various time periods and then were switched to a phosphate-depleted diet to complete 7 weeks of uraemic diet. Osteoblast like phenotype, inflammation and eventually valve calcification were observed only in rats that were fed with a phosphate-enriched regimen. Significant valv...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research