ATP-dependent chromatin remodeling complexes in embryonic vascular development and hypertension.

ATP-dependent chromatin remodeling complexes in embryonic vascular development and hypertension. Am J Physiol Heart Circ Physiol. 2019 Aug 09;: Authors: Crosswhite PL Abstract Hypertension, a chronic elevation in blood pressure, is the largest single contributing factor to mortality worldwide and the most common preventable risk factor for cardiovascular disease. High blood pressure increases the risk for someone to experience a number of adverse cardiovascular events including heart failure, stroke, or aneurysm. Despite advancements in understanding factors that contribute to hypertension, the etiology remains elusive and there remains a critical need to develop innovative study approaches in order to develop more effective therapeutics. ATP-dependent chromatin remodelers are dynamic regulators of DNA-histone bonds and thus gene expression. The goal of this review is to highlight and summarize reports of ATP-dependent chromatin remodelers contribution to the development or maintenance of hypertension. Emerging evidence from hypertensive animal models suggest that induction of chromatin remodeler activity increases pro-inflammatory genes and increases blood pressure while human studies demonstrate how chromatin remodelers may act as stress response sensors to harmful physiological stimuli. Importantly, genomic studies have linked hypertensive patients to mutations in chromatin remodeler genes. Collectively, evidence linking chromatin...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research