Pioneering stem cell procedure that doesn't just prevent hair loss but reverses it

Chris Wild, 39, from Enfield, North London, is one of the first people in Britain undergo a £2,000 pioneering stem cell procedure that doesn't just prevent hair loss but reverses it.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Abstract Hair-follicle-associated pluripotent (HAP) stem cells reside in the upper part of the bulge area of the the hair follicle. HAP stem cells are nestin-positive and keratin 15-negative and have the capacity to differentiate into various types of cells in vitro. HAP stem cells are also involved in nerve and spinal cord regeneration in mouse models. Recently, it was shown that the DNA-damage response in non-HAP hair follicle stem cells induces proteolysis of type-XVII collagen (COL17A1/BP180), which is involved in hair-follicle stem-cell maintenance. COL17A1 proteolysis stimulated hair-follicle stem-cell aging...
Source: Tissue and Cell - Category: Cytology Authors: Tags: Tissue Cell Source Type: research
Conditions:   Alopecia Areata;   Alopecia Totalis;   Alopecia Universalis Intervention:   Combination Product: Stem Cell Educator therapy combined with minoxidil Sponsors:   Tianhe Stem Cell Biotechnologies Inc.;   Yale University;   Hackensack Meridian Health Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: FN had an interesting biological effect on stem cell induction. These findings support the use of this drug for hair loss control and the development of regeneration approaches.
Source: In Vivo - Category: Research Authors: Tags: Experimental Studies Source Type: research
SummaryHair loss is a common dermatosis symptom and side-effect in cancer chemotherapeutics. Imiquimod application at mid and late telogen activated the hair follicle stem cells leading to premature hair cycle entry. Based on quinoline structure, a newly synthesized compound 6b displayed proliferation activity in vitro and in vivo through branch chain replacement and triazole ring cyclization. Toll-like receptors (TLRs) are also critical mediators of the immune system, and their activation is linked to various diseases. The present study aimed to expand new agonists within co-crystallization of TLR7 (PDB code: 5GMH); howev...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Title: Can Stem Cells Be the Cure for Baldness?Category: Health NewsCreated: 7/1/2019 12:00:00 AMLast Editorial Review: 7/2/2019 12:00:00 AM
Source: MedicineNet Skin General - Category: Dermatology Source Type: news
A potential cure for baldness using human stem cells was presented at the International Society for Stem Cell Research (ISSCR) conference on Thursday in Los Angeles.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, 45 patients were assessed using the marginal TA severity scoring system, and their biopsies (both longitudinal and transverse sections) were systematically assessed by three dermatopathologists, the aim being to correlate histopathological findings with clinical staging. Intraclass correlation coefficients were used to determine the level of agreement between the assessors. We found poor agreement of the identification and grading of perifollicular and interfollicular fibrosis (0.55 [0.23 –0.75] and 0.01 [2.20–0.41], respectively), and no correlation could be drawn with the clinical severity scor...
Source: Dermatopathology - Category: Pathology Source Type: research
Publication date: Available online 14 June 2019Source: Stem Cell ResearchAuthor(s): Nutnicha Tantarungsee, Zaukir Bostan Ali, Rungtip Soi-ampornkul, Chuda Rujitharanawong, Chanika Subchookul, Alisa Ritthaphai, Bootsakorn Boonkaew, Methichit Wattanapanitch, Kanchalit Thanomkitti, Daranporn Triwongwaranat, Chinnavuth Vatanashevanopakorn, Rattapon ThuangtongAbstractAn induced pluripotent stem cell (iPSC) line, MUSIi010-A, was established by Sendai virus (SeV) transduction of scalp fibroblasts from a 59-year-old male with androgenetic alopecia (AGA). Pluripotency of the iPSC line was verified by immunofluorescence staining of ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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