Gentamicin-Assisted Mycogenic Selenium Nanoparticles Synthesized Under Gamma Irradiation for Robust Reluctance of Resistant Urinary Tract Infection-Causing Pathogens.

Gentamicin-Assisted Mycogenic Selenium Nanoparticles Synthesized Under Gamma Irradiation for Robust Reluctance of Resistant Urinary Tract Infection-Causing Pathogens. Biol Trace Elem Res. 2019 Aug 08;: Authors: El-Sayyad GS, El-Bastawisy HS, Gobara M, El-Batal AI Abstract The purpose of this research is to compare and enhance the antimicrobial and antibiofilm potentials of the biogenic selenium nanoparticles (Se NPs) produced by cost-effective and eco-friendly green methods. The synthesis of Se NPs is described in this manuscript by two different methods: a biogenic process using Penicillium chrysogenum filtrate and by utilizing gentamicin drug (CN) following the application of gamma irradiation. Se NPs were characterized by UV-Vis., HRTM, FTIR, XRD, DLS, SEM, and EDX mapping technique. Antimicrobial and antibiofilm activities of the synthesized Se NPs were investigated against multidrug-resistant (MDR) bacteria and yeast causing severe diseases such as urinary tract infection (UTI). The biogenic Se NPs exhibited an absorption peak at 435.0 nm while Se NPs-CN showed an absorption peak at 350.0 nm which is related to the surface plasmon resonance (SPR). Data obtained from HRTEM, SEM/mapping, and XRD analysis confirmed the mono-dispersion and crystalline nature of the prepared samples with an average diameter of 33.84 nm and 22.37 nm for the mycogenic Se NPs and Se NPs-CN, respectively. The synthesized Se NPs-CN possesses an encouragin...
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research