Effect of Chlorhexidine bathing on colonization or infection with Acinetobacter baumannii-a systematic review and meta-analysis

Publication date: Available online 9 August 2019Source: Journal of Hospital InfectionAuthor(s): Cheng-Yi Fan, Wan-Ting Lee, Tzu-Chun Hsu, Cheng-Han Lee, Shiao-Pei Wang, Wen-Shan Chen, Chien-Hua Huang, Chien-Chang LeeSummaryBackgrounds: Healthcare-associated infections (HAI) caused by multidrug-resistant Gram-negative bacteria (MDRGNB) have increased prevalence in intensive care units (ICUs). A common strategy to prevent HAI is bathing patients with chlorhexidine gluconate (CHG). However, the effectiveness of CHG bathing against multidrug-resistant Acinetobacter baumannii (MDRAB) is still controversial.AimTo perform a systematic review and meta-analysis on the effectiveness of CHG bathing on Acinetobacter baumannii colonization and infection in the ICU setting.MethodsStudies searched from PubMed, EMBASE, Web of Science and CINAHL from inception through June 2018. Randomized controlled trials (RCT), pre-post studies, or interrupted time series (ITS) studies. Number of patients with/without colonization or infection of A. baumannii in the experimental or control groups were extracted from each study. Quality assessment was performed by the related instruments of National Institute of Health. Pooled risk ratios were calculated using the random-effect model.Findings1 RCT and 12 pre-post or ITS studies comprising 18,217 patients were included, of which 8,069 were in the CHG bathing arm and 9,051 in the control arm. CHG bathing was associated with a reduced colonization of A. bauman...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research

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Conclusions: Gram-negative bacteria were found to be dominant pathogens in healthcare-associated infections. The most frequently cultured pathogens were multidrug-resistant A. baumannii, K. pneumoniae ESBL(+), and P. aeruginosa. The study showed an increase in the incidence of “alert pathogens” and MDR bacilli, as well as the tendency of a growing resistance to antibiotics during the observed period. Microbiological analysis of HAIs and the consumption of antibiotics is the necessary element of the proper antibiotic policy in hospitals.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Conclusions The results of this study suggest the tested antimicrobial coating is effective against a broad range of drug-resistant pathogens. Due to its ability to reduce and inhibit bacterial growth along the prosthetic liner surface, the coating shows promise as an effective tool toward mitigating infection and malodor found at the residual limb-liner interface among persons with amputation.
Source: JPO Journal of Prosthetics and Orthotics - Category: Orthopaedics Tags: ORIGINAL RESEARCH ARTICLES Source Type: research
This report highlights our approach and management for patients with severe NP caused by multidrug ‐resistant microorganisms including timing to perform surgery and choice of antimicrobial treatment. AbstractWe report the case of a 53 ‐year‐old male that presented to our hospital with a history of a brain tumour. He was hospitalized 10 days prior in another hospital. Before surgery, he complained of mild cough. Routine chest radiography demonstrated right upper lobe consolidation which was diagnosed as hospital‐acquired p neumonia. Broad‐spectrum empirical antimicrobial was initiated. After surgery, his cl...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Acinetobacter baumannii has emerged as a major threat to global public health and is one of the key human pathogens in healthcare (nosocomial and community-acquired)-associated infections. Moreover, A. baumannii rapidly develops resistance to multiple antibiotics and is now globally regarded as a serious multidrug resistant pathogen. There is an urgent need to develop novel vaccines and immunotherapeutics as alternatives to antibiotics for clinical management of A. baumannii infection. However, our knowledge of host immune responses to A. baumannii infection and the identification of novel therapeutic targets are significa...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Authors: Hussain K, Salat MS, Ambreen G, Mughal A, Idrees S, Sohail M, Iqbal J Abstract BACKGROUND: Recently intravenous (IV) and aerosolized (ASZ) colistin have been used for treating ventilator-associated pneumonia (VAP) due to colistin susceptible multidrug-resistant Gram-negative bacteria (MDR-GNB). Colistin has limited lung penetration. We compared the efficacy and safety of IV-alone versus IV+ASZ-colistin for treating VAP in neonates. METHODS: This retrospective matched case-control-study was performed at NICU of the Aga Khan University Hospital, Pakistan between January 2015 and December 2018. Sixteen ne...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Purpose of review To describe current antimicrobial resistance in ESKAPE Gram-negative microorganisms and their situation in the ICUs, the implication of the so-called high-risk clones (HiRCs) involved in the spread of antimicrobial resistance as well as relevance of the COVID-19 pandemic in the potential increase of resistance. Recent findings Extended-spectrum and carbapenemase producing Enterobacterales and multidrug and extensive drug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii have increased worldwide. Sequence type (ST)131 Escherichia coli, ST258, ST11, ST10, ST147 and ST307 Klebsiella pneumonia...
Source: Current Opinion in Critical Care - Category: Nursing Tags: SEVERE INFECTIONS: Edited by Jean-François Timsit Source Type: research
Publication date: Available online 2 September 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Silva Tafaj, Tomislav Kostyanev, Basil B. Xavier, Ad C. Fluit, Célia F. Rodrigues, Christine Lammens, Damiana Osmalli, Lul Raka, Herman Goossens, Surbhi Malhotra-Kumar, Marc J.M. Bonten
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionDue to the high MDR and CR rates for Pseudomonas aeruginosa and Acinetobacter baumannii, isolates obtained from RTIs, IAIs, and UTIs only maintained high susceptibility rates to colistin between 2015 and 2017.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, the A. baumannii isolate bearing ISAba3-bla OXA-58 gene exhibited high resistance to imipenem, corresponding to an overexpression of bla OXA-58 gene and very high periplasmic β-lactamase activity. PMID: 32802871 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In this study, four FDA-approved drugs (besides azithromycin as positive QSI) were tested for potential QS inhibition against clinicalA. baumannii isolates andP. aeruginosa (PAO1) standard strain. The inhibitory effect of these drugs on virulence factors of both microbes has been investigated. The studied virulence factors include biofilm formation, twitching and swarming motilities, proteolytic enzyme production, and resistance to oxidative stress. The four tested drugs (erythromycin, levamisole, chloroquine, and propranolol) inhibited QS inChromobacterium violaceum by 84, 72, 55.1, and 37.3%, respectively. They also sign...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
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