Prior Appendectomy and the Onset and Course of Crohn's Disease in Chinese Patients.

Conclusion: Prior appendectomy is a risk factor for the onset of CD. However, the appendectomy rate only increased for a short duration before CD diagnosis, likely reflecting a diagnostic bias. Prior appendectomy did not influence the features or course of CD. PMID: 31396275 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

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Authors: Chiba M, Nakane K, Komatsu M Abstract Inflammatory bowel disease (IBD), a collective term for Crohn disease and ulcerative colitis, is a polygenic disease thought to be triggered by environmental factors. A Western or westernized lifestyle may be a major driver of the growing incidence of IBD. IBD may represent dysregulated mucosal inflammation to gut microbiota. Despite many review articles on environmental factors in IBD, no consensus exists regarding which factor contributes most to trigger the onset of IBD. Identification and recognition of major environmental factors are prerequisite for effective dis...
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
ConclusionThe appendix is important for intestinal homeostasis, preventing the development of certain pathologies. Its resection, regardless of whether or not there is an inflammation after surgery, increases the risk of Crohn's Disease and worsens the prognosis of this pathology, so appendectomy should be avoided in the absence of appendicitis.ResumoIntroduçãoA Doença de Crohn é um processo inflamatório crónico e idiopático com atingimento transmural que pode afetar todo o trato gastrointestinal. A etiopatogenia desta patologia não está completamente esclareci...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
ConclusionThis study highlights association between socioeconomic, dietary factors, appendectomy, and family history as risk factors for IBD.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
ConclusionThe appendix is important for intestinal homeostasis, preventing the development of certain pathologies. Its resection, regardless of whether or not there is an inflammation after surgery, increases the risk of Crohn's Disease and worsens the prognosis of this pathology, so appendectomy should be avoided in the absence of appendicitis.ResumoIntroduçãoA Doença de Crohn é um processo inflamatório crónico e idiopático com atingimento transmural que pode afetar todo o trato gastrointestinal. A etiopatogenia desta patologia não está completamente esclareci...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
CONCLUSION: Although all of the appendectomy samples were normal macroscopically, data from this study suggest that all specimens should be sent for routine investigation. KEY WORDS: Appendicitis, Appendectomy, Carcinoid, Mucocele, Endometriosis. PMID: 29339597 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
man C Abstract AIM: To identify environmental risk factors associated with the development of Crohn's disease (CD) in order to re-assess the hygiene hypothesis. METHODS: A hospital-based, case-control study was carried out with CD patients (n = 145) and controls (n = 163) representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial so...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Conclusions We identified and replicated a genetic association at 22q12.2 with tonsillectomy. Further functional investigation is required to illuminate whether the molecular mechanisms underlying the genetic association involve general lymphoid hyper-reaction throughout the mucosa-associated lymphoid tissue system.
Source: Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Genome-wide studies Source Type: research
AbstractPurpose of ReviewEnvironmental factors may influence predisposition to develop inflammatory bowel diseases (Crohn ’s disease, ulcerative colitis) or alter its natural history by modification of both the host immune response and intestinal microbial composition. The purpose of this review is to translate such evidence into clinical practice by a focus on interventional studies that have modified such environme ntal influences to improve disease outcomes.Recent FindingsSeveral environmental influences have been identified in the recent literature including tobacco use, diet, antibiotics, vitamin D deficiency, s...
Source: Current Gastroenterology Reports - Category: Gastroenterology Source Type: research
Conclusions:This meta‐analysis demonstrates that tonsillectomy is associated with an increased risk of developing CD. We found no evidence to suggest that tonsillectomy exerts a protective effect on the development of UC, as is the case with appendectomy. Further prospective studies are required to confirm the validity of these observations.
Source: Journal of Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Meta Analysis and Systematic Review Source Type: research
Abstract: The differential diagnosis of Crohn's disease (CD) and intestinal tuberculosis (ITB) remains difficult as the clinical symptoms of the 2 digestive diseases are so similar. Here we report a case where a patient was initially misdiagnosed with ITB prior to the correct CD diagnosis. The 46-year-old male patient was hospitalized elsewhere for pain in the right lower abdomen and underwent an appendectomy. The pathological diagnosis was ITB and the patient was administered antituberculosis therapy for 1 year. Afterward, the patient was readmitted to the hospital for a right lower abdominal mass. A computed tomography s...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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