Molecular Characterization of Avian Reovirus Causing Tenosynovitis Outbreaks in Broiler Flocks, Iran.

In this study, ARVs from the tendon of 23 broiler flocks with marked tenosynovitis were characterized, and their genetic relationship was examined. Analysis of the amino acid sequence of Sigma C protein revealed that all ARVs detected in affected broiler flocks share genetic homogeneity and suggests that a single genotype is involved in recent outbreaks. This genotype, so-called "Ardehal strain," is grouped in cluster I with vaccine strains. The amino acid sequence similarity between Ardehal and vaccine strain, including S1133, 1733, and 2408 was less than 80%. As the outbreaks have occurred in progenies of vaccinated flocks, it is proposed here that the difference between vaccine and field strains might contribute to the failure of currently available vaccines to induce protective immunity against Ardehal strain and this led to widespread of viral tenosynovitis in Iran. PMID: 31393165 [PubMed - as supplied by publisher]
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research

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