Rapid MALDI ‐TOF molecular imaging: Instrument enhancements and their practical consequences

AbstractA new high performance linear MALDI ‐TOF mass spectrometer provides both high spatial resolution and high speed. This instrument employs a new ion optics system with a grounded ion source and efficient transfer and detection of ions over a broad mass range. This provides very high sensitivity, precision, and an extended dynamic rang e for both positive and negative ion detection. Here we demonstrate the capabilities of this system by imaging pancreatic tissue samples from rats and mice.

Source: Journal of Mass Spectrometry - August 8, 2019 Category: Chemistry Authors: Marvin Vestal, Lingjun Li, Evgenia Dobrinskikh, Yatao Shi, Bowen Wang, Xudong Shi, Sicheng Li, Christina Vestal, Kenneth Parker Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research