Juvenile Idiopathic Arthritis: Review of the Literature and Case Report

Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Literature Review Source Type: research

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ConclusionCollectively, SP can block the loss of therapeutic potential of MSCs by preserving their proliferative and paracrine potential. This study indicates the potential of SP as a supplement in stem cell culture for therapy.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research
This study was designed to examine the effect of tadalafil, a phosphodiesterase (PDE)5 inhibitor, on the severity of joint and muscle damage in rats with adjuvant-induced arthritis (AA). Materials and methods: AA was induced by intradermal inoculation into right hind paw of male Sprague Dawley rats (300-450g) with complete Freund's adjuvant (CFA; 0.1 mL). AA rats were treated with either tadalafil (10 mg/kg; per oral) alone or along with the soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 10 mg/kg; intraperitoneally). After decapitation on day 16, trunk blood was collected for total oxi...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Conclusion: Despite low disease activity, saliva TNF-α and caspase-1 levels were found to be significantly higher in the pSjS group, which may suggest a possible advantage of local anticytokine treatments in selected cases. PMID: 29914252 [PubMed]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
In this study, we conducted comparative RNAseq experiments to detect genes associated with replicative senescence in two different human fibroblast cell lines and at different time points. We identified 841 and 900 genes (core senescence-associated genes) that are significantly up- and downregulated in senescent cells, respectively, in both cell lines. Our functional enrichment analysis showed that downregulated core genes are primarily involved in cell cycle processes while upregulated core gene enrichment indicated various lipid-related processes. We further demonstrated that downregulated genes are significantly ...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Rheumatoid arthritis (RA) patients of South Asian origin now have extra help in living with a painful and incurable condition – thanks to anew educational video that encourages them to understand when and why they need to move from standard treatment to treatment with a biologic.
Source: Rheumatology - Category: Rheumatology Source Type: research
Conclusion: In this long-term study, TCZ was effective and had a comparable safety profile to published data for TCZ use in other indications, when used for the treatment of refractory uveitis-related ME.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
(MedPage Today) -- Cardiovascular Daily wraps up the top cardiology news of the week
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news
In an open-label clinical trial, Jabbari and colleagues demonstrated clinical efficacy of the small molecule JAK1,3 inhibitor tofacitinib in 12 patients with moderate-to-severe alopecia areata (AA), a disease that results from autoimmune attack on the hair follicles with resulting significant hair loss. Tofacitinib, which has previously been approved for treatment of rheumatoid arthritis, halted hair loss and allowed considerable regrowth in 11 of these patients without serious adverse effects. Although the therapy is non-curative, as evidenced by relapse after treatment cessation, tofacitinib is a promising therapy for th...
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Editorial Source Type: research
Authors: Bartoli F, Bae S, Cometi L, Matucci Cerinic M, Furst DE Abstract INTRODUCTION: Interleukin-6 (IL-6) is well-known for its pro-inflammatory properties, has been proven to target a wide range of cells in the joint and has been implicated in extra-articular and articular manifestations in rheumatoid arthritis (RA). Tocilizumab (TCZ) is now widely used in patients with active RA and a number of additional agents that target the IL-6 pathways are under development, including sirukumab (SRK). Areas covered: SRK is a IgG1κ human anti-IL-6 monoclonal antibody which binds to IL-6 and prevents IL-6 mediated do...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
-- Rheumatoid arthritis is a chronic disease that causes considerable pain in joints. At some point, most people with RA develop pain in the ankle and foot. While there is no cure, the American Academy of Orthopaedic Surgeons says there are things...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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