Efficacy and safety of 25 and 50 μg desmopressin orally disintegrating tablets in Japanese patients with nocturia due to nocturnal polyuria: Results from two phase 3 studies of a multicenter randomized double‐blind placebo‐controlled parallel‐group development program

This study assessed the efficacy and safety of desmopressin orally disintegrating tablets (ODTs) in Japanese males (50 and 25  μg) and females (25 μg) with nocturia due to nocturnal polyuria (NP). Two Phase 3 randomized double‐blind placebo‐controlled studies of 342 males and 190 females with nocturia due to NP were conducted. The primary endpoint was change from baseline in mean number of nocturnal voids. In add ition, time to first awakening to void, nocturnal urine volume, NP index (NPI), and quality of life were assessed during a 12‐week treatment period. In males, 50 and 25 μg desmopressin ODTs significantly reduced the number of nocturnal voids by −1.21 (P 
Source: LUTS: Lower Urinary Tract Symptoms - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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In conclusion, the cryogel granted a safe and satisfactory cleaning action and a residue-free soil removal from acrylic paint films, overcoming the drawbacks of traditional cleaning methods.
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: Available online 16 October 2019Source: Journal of Molecular LiquidsAuthor(s): Yichao Shen, Yong Jin, Shuangquan Lai, Liangjie Shi, Weining Du, Rong ZhouAbstractDeveloping suitable alternatives to long fluoroalkyl chain surfactants has drawn considerable attention on account of the concerns over the environmental safety and human health. However, low surface activity, poor water solubility and complex preparation process of most currently reported alternatives restrict their widespread applications. Herein, a series of nonionic urethane fluorinated surfactants (FmEGnFm) were synthesized by one-pot method ...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 15 October 2019Source: Chemical Engineering and Processing - Process IntensificationAuthor(s): F. Stauffer, B. Peter, H. Alem, D. Funfschilling, N. Dumas, C.A. Serra, T. Roques-CarmesAbstractThe fabrication of stable double emulsions remains a challenge in many industrial applications and appears as a hot topic in the microfluidics field. We apply a novel approach to selectively modify the wetting properties of the walls of the micro-emulsifier by deposing successive layers of polyelectrolytes on the targeted sections of the microsystems. The PDMS surface of a microfluidic droplet generat...
Source: Chemical Engineering and Processing: Process Intensification - Category: Chemistry Source Type: research
Soft Matter, 2019, Accepted Manuscript DOI: 10.1039/C9SM01091B, PaperJonathan Cimadoro, Laura Ribba, S. Goyanes, Enrique Cerda While important research efforts have been focused on developing surfaces that do not wet, some textures with high wetting resistance are familiar in other applications where the opposite is needed.... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research
Publication date: November 2019Source: Colloid and Interface Science Communications, Volume 33Author(s): Ram Krishna Upadhyay, Arvind KumarAbstractEpoxy-graphene composites are prepared with varying graphene concentration of 1 wt%, 3 wt%, and 5 wt%. Composite fabrication involves continuous stirring of the mixture consisting graphene and epoxy resin followed by curing first at room temperature and subsequently at 100 °C. In the epoxy-graphene composites, compressive stresses show increasing trend with filler concentration. A correlation between surface roughness and wetting is established to explain the Wenzel'...
Source: Colloids and Interface Science Communications - Category: Nanotechnology Source Type: research
Abstract Toilet training is a significant developmental milestone in early childhood. Most U.S. children achieve the physiologic, cognitive, and emotional development necessary for toilet training by 18 to 30 months of age. Markers of readiness for toilet training include being able to walk, put on and remove clothing, and follow parental instruction; expressive language; awareness of a full bladder or rectum; and demonstrated dissatisfaction with a soiled diaper. Other readiness cues include imitating toileting behavior, expressing desire to toilet, and demonstrating bladder or bowel control (staying dry through ...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Publication date: Available online 11 October 2019Source: Bioactive Carbohydrates and Dietary FibreAuthor(s): Digambar Kavitake, Farhat Zakirhusain Marchawala, Cedric Delattre, Prathapkumar Halady Shetty, Hilor Pathak, Prasad AndhareAbstractSuccinoglycan exopolysaccharide (EPS) from Rhizobium radiobacter CAS and its rheological behavior has been studied earlier. In present investigation the emulsifying potential of CAS EPS has been determined. CAS EPS concentration was optimized with hydrocarbons soybean oil and n-Hexane, whereas effect of pH (3.0–11.0), salinity, monovalent ions, divalent ion, (NaCl, KCl and MgCl2),...
Source: Bioactive Carbohydrates and Dietary Fibre - Category: Food Science Source Type: research
Publication date: Available online 11 October 2019Source: Materials LettersAuthor(s): Zeqin Cui, Zhen Qin, Peng Dong, Yunjun Mi, Dianqing Gong, Weiguo LiAbstractThe FeCoNiCrMn high-entropy alloy (HEA) coatings were prepared by high-speed laser cladding (HSLC) technology, and the surface was subjected to ultrasonic surface mechanical rolling treatment (SMRT). After SMRT, the surface of the coatings show a gradient structure. The coatings consist of planar crystal, columnar dendrites and equiaxed crystals from inside to outside. Corrosion behavior in a 3.5% NaCl solution indicates that SMRTed coatings exhibit higher corrosio...
Source: Materials Letters - Category: Materials Science Source Type: research
Publication date: 1 January 2020Source: Materials Letters, Volume 258Author(s): Changji Xuan, Keiji Nakajima, Hiroyuki Shibata, Pär Göran JönssonAbstractThis work reported the wetting and spreading behavior of pure iron droplet on single crystal TiO2 substrate. During the heating process, a “FeO·TiOx separated liquid phase” appeared at the temperature below the melting point of the pure iron, and completely covered the lower half of the iron droplet. The observed high-wetting behavior of the droplet is due to the spreading of the “separated liquid phase” rather than the iron dr...
Source: Materials Letters - Category: Materials Science Source Type: research
Abstract Primary nocturnal enuresis (PNE) is always associated with attention impairment, some of which even could develop to attention deficit hyperactivity disorder. The mechanism of attention impairment is not clear, especially lacking of objective indicators of neuroimaging. The aim of this study is to explore the possible functional imaging mechanism of impaired attention in PNE children. A total of 26 PNE children and 26 age-matched normal controls were recruited. Resting-state functional magnetic resonance imaging (rs-fMRI) was performed on these children. Degree centrality (DC) of key brain regions of DAN ...
Source: International Journal of Developmental Neuroscience - Category: Neuroscience Authors: Tags: Int J Dev Neurosci Source Type: research
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