Convolutional neural network-based segmentation can help in assessing the substantia nigra in neuromelanin MRI

ConclusionU-net segmentation provided relatively high accuracy in the evaluation of the SNpc in NM-MRI and yielded diagnostic performance comparable to that of the established manual method.
Source: Neuroradiology - Category: Radiology Source Type: research

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Conclusion: Anti-CV2 autoimmune encephalitis can present as Parkinsonism with bilateral leukoencephalopathy on MRI. PET scanning can be useful to reveal an occult cancer. Treatment of the cancer may improve the paraneoplastic neurological syndrome without the need of immunosuppressive therapy.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Objective: To investigate the dynamic amplitude of low-frequency fluctuations (dALFFs) in patients with Parkinson's disease (PD) and healthy controls (HCs) and further explore whether dALFF can be used to test the feasibility of differentiating PD from HCs.Methods: Twenty-eight patients with PD and 28 demographically matched HCs underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans and neuropsychological tests. A dynamic method was used to calculate the dALFFs of rs-fMRI data obtained from all subjects. The dALFF alterations were compared between the PD and HC groups, and the correlations between dA...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
French researchers are developing what they say will be the most powerful magnetic resonance imaging (MRI) scanner in the world, which will use a supermagnet the weight of a blue whale and should allow earlier diagnosis of diseases such as Parkinson's.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
French researchers are developing what they say is the most powerful Magnetic Resonance Imaging (MRI) scanner in the world which will use a supermagnet the weight of a blue whale and should allow earlier diagnosis of diseases such as Parkinson's.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Conclusion: The T1-weighted pallidal signal is associated with occupational Mn exposure and severity of parkinsonism.
Source: Journal of Occupational and Environmental Medicine - Category: Occupational Health Tags: ORIGINAL ARTICLES Source Type: research
Conclusions. These findings support the hypothesized compensatory shift in which the dysfunctional striatum is assisted by the less affected cerebellum to accomplish lower limb movement in individuals with mild-moderate PD. These findings are of relevance for postural control disorders and freezing of gait problems frequently noted in many people with PD.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: The 18F-P3BZA PET/MRI clearly images the neuromelanin in the substantia nigra, suggesting it is a potential probe for imaging neurological diseases associated with neuromelanin abnormal expression such as PD.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Brain Imaging Targets Source Type: research
Conclusions: The use of antidepressants, especially SNRIs, was associated with a shorter survival time of sCJD patients. The possible changes in neurotransmitters should be emphasized. Scientifically, this study may provide insights into the mechanism of CJD. Clinically, it may contribute to the early diagnosis of CJD.IntroductionDepression is common in the elderly. Its prevalence rate is as high as 11.19%, and this increases progressively with worsening cognitive impairment (1). The presence of depression is an acknowledged risk factor for dementia (2); it can even double the risk for Alzheimer’s disease (AD) (3, 4)...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In conclusion, our study demonstrates that TS patients manifest “trait” abnormalities in the timing of sequential motor tasks, which are in keeping with the continuation phase of time processing, likely controlled by the sensorimotor loop of the cortico-basal ganglia network. We also show that the abnormal lateralization of fine motor control, previously reported in the context of the structural sequencing of fine motor tasks, extends also to motor timing accuracy. Finally, we highlight SMA connectivity as a potentially pivotal neural substrate of adaptive compensation of motor timing deficits in fine manual ta...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion Taken together, evidence from animal and human studies demonstrates that the brain detects levels of circulating nutrients and hormones and consequently organizes an outward response that contributes to the regulation of whole-body glucose homeostasis. However, there are major knowledge gaps about the exact nature of this response and its relative importance compared to peripheral processes. As we have seen, animal studies have provided an anatomical map of CNS glucose regulation and have identified important neurons and neural circuits involved. Additionally, the CNS sensing of key nutrients and hormones has b...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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