Longitudinal changes in fasting and glucose-stimulated GLP-1 and GIP in healthy older subjects.

CONCLUSIONS: Fasting GIP, and glucose-stimulated GLP-1 and GIP concentrations correlate within individuals over a follow-up period of ∼ 5.9 years. Aging is associated with reductions in fasting GLP-1 and GIP, and glucose-stimulated GLP-1, which may predispose to the development of glucose intolerance and type 2 diabetes.
PMID: 31393567 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - August 7, 2019 Category: Endocrinology Authors: Pham H, Marathe CS, Phillips LK, Trahair LG, Hatzinikolas S, Huynh L, Wu T, Nauck MA, Rayner CK, Horowitz M, Jones KL Tags: J Clin Endocrinol Metab Source Type: research