Clinical impact of genomic analysis in children with B-acute lymphoblastic leukemia: A pilot study in Slovakia.

In this study we reviewed 133 B-ALL patients. We found that nearly 40% of them (52 cases) belonged to the B-other ALL group. Eighteen B-other ALL patients were subjected to the analysis using SNP-array. Overall, we identified 126 cytogenomic changes and in 4 patients the SNP array revealed clinically relevant markers of adverse prognosis and high relapse risk. Integrating identified genetic changes into clinical practice can bring improvement of prognosis assessment for children with ALL in Slovakia.
PMID: 31390871 [PubMed - as supplied by publisher]

Source: Neoplasma - August 3, 2019 Category: Cancer & Oncology Authors: Vaska A, Makohusova M, Plevova K, Skalicka K, Cermak M, Chovanec F, Fabri O, Svec P, Kolenova A Tags: Neoplasma Source Type: research