Detecting schizophrenia at the level of the individual: relative diagnostic value of whole-brain images, connectome-wide functional connectivity and graph-based metrics.

CONCLUSION: These results were replicated across the three employed ML approaches. Connectome-wide functional connectivity permits differentiation of patients with schizophrenia from healthy controls at single-subject level with greater accuracy; this pattern of results is consistent with the 'dysconnectivity hypothesis' of schizophrenia, which states that the neural basis of the disorder is best understood in terms of system-level functional connectivity alterations.
PMID: 31391132 [PubMed - as supplied by publisher]

Source: Psychological Medicine - August 7, 2019 Category: Psychiatry Authors: Lei D, Pinaya WHL, van Amelsvoort T, Marcelis M, Donohoe G, Mothersill DO, Corvin A, Gill M, Vieira S, Huang X, Lui S, Scarpazza C, Young J, Arango C, Bullmore E, Qiyong G, McGuire P, Mechelli A Tags: Psychol Med Source Type: research