Estimated incubation period for mosquito-borne disease-related Guillain-Barre syndrome

ConclusionsThe incubation period of GBS follows Sartwell's model. It should be useful in confirming the association between infection and GBS in epidemiologic studies as well as to assist diagnosis and prognosis such as clinically assessing respiratory failure. It is also found that viral symptoms can occur prior to neurological symptoms, suggesting that GBS may be a parainfectious disease.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research

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Adriano Queiroz1, Isabella Fernanda Dantas Pinto2, Maricélia Lima3, Marta Giovanetti1,4, Jaqueline Goes de Jesus1, Joilson Xavier1, Fernanda Khouri Barreto5, Gisele André Baptista Canuto6, Helineide Ramos do Amaral7, Ana Maria Bispo de Filippis4, Denise Lima Mascarenhas8, Melissa Barreto Falcão8, Normeide Pedreira Santos8, Vasco Ariston de Carvalho Azevedo9, Marcos Yukio Yoshinaga2*, Sayuri Miyamoto2 and Luiz Carlos Junior Alcantara1,4,10* 1Laboratório de Patologia Experimental, Instituto Gonçalo Moniz, Salvador, Brazil 2Departamento de Bioquímica, Instituto de Quími...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion and Perspectives Arbovirus infections, such as CHIKV, have been growing worldwide and are becoming a major public health problem, especially in immuno-compromised classes such as children and the elderly. CHIKV is dangerous since it can cause arthritis, fever and other impairments, making it necessary to seek new ways to counter the proliferation of this virus. Knowing the vector’s competence is fundamentally important, including an understanding of the vector virus interaction and the modulation of this interaction. Despite advances in the knowledge of mosquito competence in the transmission of CHIKV, li...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionsThe results of the review reaffirmedCampylobacter jejuni as the major trigger of GBS, whereas the association of influenza vaccines and GBS is less clear: Zika virus infection in association with GBS was found in only one study.This article is protected by copyright. All rights reserved.
Source: Tropical Medicine and International Health - Category: Tropical Medicine Authors: Tags: Systematic Review Source Type: research
Zika virus (ZIKV) is a mosquito-borne flavivirus that is responsible for recent explosive epidemics in the Americas. Notably, ZIKV infection during pregnancy has been found to cause congenital birth defects, including microcephaly, and ZIKV has been associated with Guillain-Barré syndrome in adults. Diagnosis and surveillance of Zika in the Americas have been challenging due to similar clinical manifestations and extensive antibody cross-reactivity with endemic flaviviral diseases, such as dengue. We evaluated four serological and two reverse transcription-PCR (RT-PCR) methods in acute-phase (mean day, 1.8), early-c...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Virology Source Type: research
This study accessed the patients information on demographic characteristics, physical signs and symptoms. Study population This is a cross-sectional and observational study carried out in Brazil during DENV and ZIKV epidemic occurred in 2016. Patients were assisted at the Healthy Unit UPA Coronel Antonino in Campo Grande, MS, Brazil from February to March of 2016. During the study 134 suspected arboviral infection cases were included and submitted to investigation. Patients presenting fever, rash during acute phase of infection (up to the 7th day after disease onset) followed by at least two of the following signals a...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
ConclusionsZika virus is associated with a wide range of neurological manifestations, including central nervous system disease. Chikungunya virus appears to have an equally important association with neurological disease in Brazil, and many patients had dual infection. To understand fully the burden of Zika we must look beyond GBS, and also investigate for other co-circulating arboviruses, particularly chikungunya.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
FINDINGSA new study demonstrates that outbreaks of mosquito-borne viruses Zika and Chikungunya generally occur about three weeks after heavy rainfall.Researchers also found that Chikungunya will predominate over Zika when both circulate at the same time, because Chikungunya has a shorter incubation period — just two days, versus 10 days for Zika. The latter finding explains why a late-2015 Zika epidemic in Rio de Janeiro ended while the number of Chikungunya cases increased in February 2016.BACKGROUNDViruses transmitted by insects can lead to serious health repercussions. Zika is linked to birth defects, and up to 1 ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
The objective of this study was to assess the mortality associated with chikungunya epidemics in Brazil by comparing the mortality of pre-chikungunya with mortality during chikungunya epidemics2,3. Methods We studied the 3 Brazilian states with higher chikungunya incidence rates (IR), Pernambuco (9,410,772 inhabitants), Rio Grande do Norte (3,474,998 inhabitants), and Bahia (15,498,733 inhabitants)5. Bahia is the largest and most populated state, with a heterogeneous incidence of chikungunya, and therefore we analyzed separately each one of 9 administrative regions of Bahia. We retrospectively analyzed anonymous, publicly...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
We report the results of a rapid assessment of Zika virus awareness among key clinical specialties in Singapore, with the aim of identifying gaps in knowledge and opportunities for improving communication on Zika virus disease management and control policies. Methods Study Participants and Sites Between June 6 and June 19, 2016 prior to the Zika virus outbreak, we conducted an online survey of doctors working in obstetrics and gynaecology, neonatology and paediatrics in Singapore. A link to the online survey was disseminated by email to the relevant doctors at KK women’s and Children’s Hospital and Singapo...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
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