Dose optimization of valproic acid in a lethal model of traumatic brain injury, hemorrhage and polytrauma in swine - Biesterveld BE, Williams AM, Pai MP, Dennahy IS, Graham NJ, Chtraklin K, Siddiqui AZ, O'Connell RL, Bhatti UF, Liu B, Russo RM, Li Y, Alam HB.

BACKGROUND: Trauma is a leading cause of death, and traumatic brain injury (TBI) is one of the hallmark injuries of current military conflicts. VPA administration in high doses (300-400 mg/kg) improves survival in lethal trauma models, but effectiveness of...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Program and Other Evaluations, Effectiveness Studies Source Type: news

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BACKGROUND: Early identification of traumatic intracranial hemorrhage (ICH) has implications for triage and intervention. Blood-based biomarkers were recently FDA approved for prediction of ICH in patients with mild TBI. We sought to determine if biomarker...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Conclusions: The evidence from the present study indicates that lobectomy can be an acceptable surgical procedure in management of TBI patients with delayed contusion or ICH. 
Source: Journal of Injury and Violence Research - Category: International Medicine & Public Health Source Type: research
Dear colleagues, I have an 80 years old patients known to have a lung adenocarcinoma since 2017, treated with systemic treatments and one course of brain SRS in 2017 with complete remission of the lesions. he presents with two solitary brain lesions one right frontal of 4mm another right post parietal of 26 mm with intralesional hemorrhage and important peri-lesional edema (no midline shift ), inoperable do you take in consideration the perilesional edema to decide for one Shot SRS or... Does periolesional edema influence dose prescriptin/fractionation for SRS brain mets?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
CONCLUSIONS: Telemedicine has provided Victorian regional hospitals access to expert care for emergency department patients with suspected acute stroke. Eligible patients with ischaemic stroke are now receiving stroke thrombolysis more quickly and safely. PMID: 32255520 [PubMed - as supplied by publisher]
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
Conclusion: Cerebral aneurysm coiling could be considered as the first choice of treatment in the case of acute MI with hemodynamic stability, before carrying out cardiac endovascular intervention or antiplatelet medication to reduce the risk of rebleeding from a brain aneurysm. PMID: 32257575 [PubMed - as supplied by publisher]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusion: Combined LOC at ictus and/or poor initial WFNS grade (3-5) reflects the impact of EBI and was a useful surrogate marker of poor prognosis in SAH patients, independent of patients' age and state of DCI. PMID: 32257566 [PubMed - as supplied by publisher]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
AbstractIntracerebral haemorrhage (ICH) is responsible for disproportionately high morbidity and mortality rates. The most used ICH classification system is based on the anatomical site. We used SMASH-U, an aetiological based classification system for ICH by predefined criteria: structural vascular lesions (S), medication (M), amyloid angiopathy (A), systemic disease (S), hypertension (H), or undetermined (U). We aimed to correlate SMASH-U classification of our patients to the intra-hospital mortality rates. We performed a single centre retrospective study at the Santa Maria Della Misericordia Hospital, Perugia (Italy) inc...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
Blue rubber bleb nevus syndrome (BRBNS), also called Bean's syndrome, is a rare disease associated with multiple venous malformations in the skin and gastrointestinal (GI) tract. Dermatological lesions, which are the first clinically visible manifestations, appear as skin-colored compressible protuberances or as dark-blue venous nodules, rubbery in consistency. Central nervous system (CNS) manifestations are rare, variable, non-specific, and tend to occur late in the disease, mainly reported as seizures and focal neurological deficits secondary to compression. Most cases occur sporadically, however, an autosomal dominant i...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Ischemic stroke damages the blood-brain barrier (BBB), which leads to brain edema and increases the risk of intracranial hemorrhage. Proteasome inhibition has been found to protect the BBB against cerebral ischemia by suppressing neuroinflammation-mediated matrix metalloproteases-9 (MMP-9) activation. We recently showed that ginsenoside Rd (Rd), a major active ingredient of Panax ginseng, could suppress proteasome-mediated inflammation and be efficient for treating ischemic stroke but downstream mechanisms were still unidentified. For this purpose, Sprague–Dawley rats were subjected to focal cerebral ischemic injury....
Source: NeuroReport - Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Mural cells synthesize and deposit laminin to the basement membrane. To investigate the function of mural cell-derived laminin, we generated a mutant mouse line lacking mural cell-derived laminin (termed PKO)....
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
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