Artificial intelligence could yield more accurate breast cancer diagnoses

UCLA researchers have developed an artificial intelligence system that could help pathologists read biopsies more accurately and to better detect and diagnose breast cancer.The new system,described in a study published today in JAMA Network Open, helps interpret medical images used to diagnose breast cancer that can be difficult for the human eye to classify, and it does so nearly as accurately or better as experienced pathologists.“It is critical to get a correct diagnosis from the beginning so that we can guide patients to the most effective treatments,” said Dr. Joann Elmore, the study’s senior author and a professor of medicine at theDavid Geffen School of Medicine at UCLA.A 2015 study led by Elmore found that pathologists often disagree on the interpretation of breast biopsies, which are performed on millions of women each year. That earlier research revealed that diagnostic errors occurred in about one out of every six women who had ductal carcinoma in situ (a noninvasive type of breast cancer), and that incorrect diagnoses were given in about half of the biopsy cases of breast atypia (abnormal cells that are associated with a higher risk for breast cancer).“Medical images of breast biopsies contain a great deal of complex data and interpreting them can be very subjective,” said Elmore, who is also a researcher at theUCLA Jonsson Comprehensive Cancer Center. “Distinguishing breast atypia from ductal carcinoma in situ is important clin...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Conclusions: the factors associated with cervical adenocarcinoma were ≥ 40 years old, ≤ 3 years of schooling, black race, menopausal status, never had undergone cervical cancer screening and the presence of HPV.Resumo Objetivos: determinar a incid ência dos principais Papilomavirus Humano (HPV) de alto risco oncogênico (16, 18, 31 e 33) e os fatores associados ao adenocarcinoma do colo uterino. Métodos: realizado estudo de caso-controle com 324 mulheres (69 com adenocarcinoma e 260 controles saudáveis), de 2001 a 2014. Foram colhidas inf ormações sobre fatores de risco associad...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Publication date: Available online 15 September 2019Source: Advances in Biological RegulationAuthor(s): Yi Cai, Andrew Yousef, Jennifer R. Grandis, Daniel E. JohnsonAbstractEpidemiologic evidence indicates that regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) provides a protective effect against the development of colorectal, breast, and head and neck cancers. Genomic characterization of these cancers has lent considerable insight into the subpopulations of cancer patients who are most likely to benefit from NSAID therapy. The PIK3CA gene encodes the catalytic subunit of phosphatidylinositol 3-kinase (PI3K) and...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
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Source: Advances in Biological Regulation - Category: Biology Source Type: research
Publication date: Available online 15 September 2019Source: Reactive and Functional PolymersAuthor(s): Muhammad Sohail, Binish Ashfaq, Iqra Azeem, Amir Faisal, Sema Yiyit Do─čan, Jianjun Wang, Hatice Duran, Basit YameenAbstractA convenient UV-curable coatings assisted surface functionalization strategy is presented to convert commodity Poly(propylene) (PP) films into diverse functional materials. To ensure a covalent integration between PP surface and functional UV-curable coatings, 3-(trimethoxysilyl) propyl acrylate (TMSPA) was functionalized on the surface of oxidized PP film. Two distinct UV-curable coatings differing ...
Source: Reactive and Functional Polymers - Category: Chemistry Source Type: research
Publication date: 25 November 2019Source: Journal of Industrial and Engineering Chemistry, Volume 79Author(s): Su-Un Lee, You-Jin Lee, Jeong-Rang Kim, Kwang-Eun Jeong, Soon-Yong JeongAbstractSilicoaluminophsophate (SAPO)-34 is considered as a promising catalyst for methanol-to-olefin (MTO) reaction, because its cylinder-like cages with small 8-ring pore openings restrict the diffusion of large hydrocarbons and exceptionally give high selectivity for light olefins. However, its main drawback is rapid catalytic deactivation by heavy hydrocarbons confined inside the cages. Here, we report a facile synthetic strategy for submi...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
We report the fabrication of bimetallic NiCo2Se4 and CoNi2Se4 nanostructures on nickel-foam (Ni-foam) substrates via a potentiostatic-deposition method by adjusting the molar ratio of Ni and Co metals. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses show that burl-like clusters with characteristic fluffy NiCo2Se4 and flake-like CoNi2Se4 hierarchical structures were deposited on the Ni-foam substrates. When used as battery-type electrodes in supercapacitors, both NiCo2Se4 and CoNi2Se4 electrodes exhibited outstanding capacity and good electrochemical properties. The CoNi2Se4 electrode ...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Authors: Roguljic A, Spagnoli G, Juretic A, Sarcevic B, Banovic M, Beketic Oreskovic L Abstract Cancer/testis antigens (CTAs) are a large family of tumor-associated antigens expressed in human tumors of different histological origin, but not in normal tissues, with the exception of the testes and placenta. Numerous immunohistochemical studies have reported associations between CTA expression and a negative estrogen receptor (ER) status in breast tumors, and demonstrated that CTAs are frequently expressed in tumors with higher nuclear grade. The expression of CTAs has not been studied as extensively in ductal carcin...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Author Affiliations open 1Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA 2Social &Scientific Systems, Inc., Durham, North Carolina, USA 3Westat, Durham, North Carolina, USA 4Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway 5Biostatistics and Computational Biology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA PDF Version (548 KB) Abstract About This Article Supplemental Material Bac...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
It is unclear whether cancer and its treatments increase the risk of adverse pregnancy outcomes. Our aim was to examine whether cancer survivors have higher risks of poor outcomes in pregnancies conceived after diagnosis than women without cancer, and whether these risks differ by cancer type and race. Diagnoses from cancer registries were linked to pregnancy outcomes from birth certificates in three U.S. states. Analyses were limited to the first, live singleton birth conceived after diagnosis. Births to women without a previous cancer diagnosis in the registry were matched to cancer survivors on age at delivery, parity, ...
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Cancer Epidemiology Source Type: research
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