Abnormalities in Proinsulin Processing in Islets from Individuals with Longstanding T1D

We recently described the persistence of detectable serum proinsulin in a large majority of individuals with longstanding type 1 diabetes (T1D), including individuals with undetectable serum C-peptide. Here, we sought to further explore mechanistic etiologies of persistent proinsulin secretion in T1D at the level of the islet, using tissues obtained from human donors. Immunostaining for proinsulin and insulin was performed on human pancreatic sections from the Network for Pancreatic Organ Donors with Diabetes (nPOD) collection (n=24).

Source: Translational Research - August 8, 2019 Category: Research Authors: Emily K. Sims, Farooq Syed, Julius Nyalwidhe, Henry T. Bahnson, Leena Haataja, Cate Speake, Margaret A. Morris, Appakalai N. Balamurugan, Raghavendra G. Mirmira, Jerry Nadler, Teresa L. Mastracci, Peter Arvan, Carla J. Greenbaum, Carmella Evans-Molina Source Type: research