How Exercise Lowers the Risk of Alzheimer ’s by Changing Your Brain

In this study, they showed that intervening with an exercise regimen could actually affect these processes. Taken together, his body of research is establishing exactly how physical activity contributes to significant changes in the biological processes that drive Alzheimer’s, and may even reduce the effect of strong risk factors such as age and genes linked to higher risk of neurodegenerative disease. For example, in their earlier work his group confirmed that as people age, the presence of Alzheimer’s-related brain changes increases—including the buildup of amyloid, slower breakdown of glucose by brain cells, shrinking of the volume of the hippocampus (central to memory), and declines in cognitive function measured in standard recall and recognition tests. But they found that in people who reported exercising at moderate intensity at least 150 minutes a week, as public health experts recommend, brain scans showed that these changes were significantly reduced and in some cases non-existent compared to people who were not active. “The association between age and Alzheimer’s brain changes was blunted,” says Okonkwo, “Even if [Alzheimer’s] got worse, it didn’t get worse at the same speed or rate among those who are physically active as in those who are inactive.” In another previous study, they found the benefits of exercise in controlling Alzheimer’s processes even among those with genetic predisposition for the...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Brain Exercise/Fitness Source Type: news

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DiscussionThese findings reveal that visuospatial deficits may derive from distinct brain alterations in AD and DLB. We propose that the inabilities to perform correctly the QSPT task is related to altered visuoperceptual process in DLB, and visuospatial process in AD. This is consistent with our results showing hypometabolism in brain system related to visuoperceptual processing, namely the occipital cortex in DLB, and visuospatial processing, namely parietal cortex in AD.
Source: Neuropsychologia - Category: Neurology Source Type: research
Maintaining fitness through the practice of regular exercise improves health in old age, slowing the pace of damage to the brain and consequent cognitive decline. While there is largely only correlational data in humans to show a link between exercise and a slower pace of neurodegeneration, many animal studies make it clear that exercise causes an improved trajectory for health in later life. It does not extend overall life span in mice, as is the case for calorie restriction, but is otherwise very effective for an intervention that is essentially free. This beneficial outcome is likely due to a combination of overl...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
CONCLUSIONS: Scan recipients were willing to accept a treatment with a high risk of death. Discordance was affected by scan recipient's having poorer functioning. PMID: 31414990 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
This study included ten controls, 19 amnestic mild cognitive impairment, and 10 AD dementia subjects. Within-subject regional correlations between modalities, between-group regional and voxel-wise analyses of covariance per modality, and receiver operating characteristic analyses for discrimination between groups were performed. RESULTS: FDG standardized uptake value ratio, eAV45 (0-2 min) standardized uptake value ratio, and AV45-R1 were significantly associated with H2O PET (regional Pearson r = 0.54-0.82, 0.70-0.94, and 0.65-0.92, respectively; P 
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
This study included ten controls, 19 amnestic mild cognitive impairment, and 10 AD dementia subjects. Within-subject regional correlations between modalities, between-group regional and voxel-wise analyses of covariance per modality, and receiver operating characteristic analyses for discrimination between groups were performed.ResultsFDG standardized uptake value ratio, eAV45 (0–2 min) standardized uptake value ratio, and AV45-R1 were significantly associated with H2O PET (regional Pearson r = 0.54–0.82, 0.70–0.94, and 0.65–0.92, respectively; P 
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
The growing utility of medical imaging technologies for detecting early signs...Read more on AuntMinnie.comRelated Reading: PET model tracks beta amyloid, Alzheimer's risk PET shows how women are more susceptible to Alzheimer's Florbetapir-PET links lack of financial acumen to dementia IDEAS study confirms amyloid PET's value for Alzheimer's Are amyloid PET scans ready for the clinical setting?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
CONCLUSION: The total MoCA-J score correlated with amyloid deposition and frontal and parietal glucose metabolism in subjects with mild cognitive impairment. Our findings support the usefulness of the MoCA-J test for screening subjects at high risk for Alzheimer's disease. PMID: 31385770 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research
One expert warns of “unintended downsides,” including overuse of only modestly effective medications.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Alzheimer ' s Disease Elderly Memory Tests (Medical) Drugs (Pharmaceuticals) Dementia Brain Source Type: news
;ly K Abstract The ever-growing average age of the society significantly increases the occurrence of Alzheimer's disease. The increased prevalence represents considerable social and economic burden, which urges the development of diagnostic and therapeutic methods in the field. The most common cause of dementia is Alzheimer's disease, the typical histopathological abnormality of which are well known. The detection of functional changes results in the early diagnosis of the disease, which precedes the morphological changes by years. Positron-emission tomography plays an important role in the demonstration of metabo...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research
Publication date: Available online 22 July 2019Source: NeuroImage: ClinicalAuthor(s): Leonie Beyer, Jonas Schnabel, Philipp Kazmierczak, Michael Ewers, Sonja Schönecker, Catharina Prix, Johanna Meyer-Wilmes, Marcus Unterrainer, Cihan Catak, Oliver Pogarell, Robert Perneczky, Nathalie L. Albert, Peter Bartenstein, Adrian Danek, Katharina Bürger, Johannes Levin, Axel Rominger, Matthias BrendelAbstractObjectivesMany predictive or influencing factors have emerged in investigations of the cognitive reserve model of patients with Alzheimer's disease (AD). For example, neuronal injury, which correlates with cognitive de...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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