Blood neurofilament light chain at the doorstep of clinical application

Multiples sclerosis (MS) is a chronic progressive disorder of the CNS with inflammatory and neurodegenerative pathomechanisms leading to various degrees of neurologic disability. In the past 2 decades, high-efficacy disease-modifying therapies (DMTs) have become available that lead to near-complete suppression of acute disease activity (relapses, lesion formation) in most patients, and only a small number of patients exhibit an aggressive disease course despite adequate use of DMTs. Here, immunoablation followed by stem cell transplantation (SCT) has emerged in recent years as an efficacious approach to stop acute disease activity, based on the concept of a reset of the immune system. However, DMTs show minimal effect on the course of progression. Accordingly, 30% (7/23) of patients continue to experience clinical progression and additional brain atrophy as its MRI equivalent 12 months after SCT.1
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Clinical trials Observational study (Cohort, Case control), Class II, Multiple sclerosis Editorial Source Type: research