Inflamm-aging micrornas may integrate signals from food and gut microbiota by modulating common signalling pathways

Publication date: Available online 8 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Laura Teodori, Ilaria Petrignani, Angelica Giuliani, Francesco Prattichizzo, Felicia Gurău, Giulia Matacchione, Fabiola Olivieri, Sofia Coppari, Maria Cristina AlbertiniAbstractHuman gut microbiota, which comprises an extremely diverse and complex community of microorganisms inhabiting the intestinal tract, may be associated with inflammation and age-related chronic health conditions. However, the mechanism underlying this association is only recently beginning to emerge. Transfer and modulation of gene expression by diet-derived microRNAs (miRs) in mammals might be involved in this communication. Through a bioinformatics approach, using on line tools and repositories, we searched for evidences that food-containing miRs, actually involved in the modulation of the inflammatory process, (inflamma-miRs), may contribute to mediate the anti-inflammatory effects exerted by some foods through the modulation of aging-related pathways and gut microbiota composition in a bidirectional communication. Supported by a” Pubmed” search and our previous research, a trio of experimentally validated inflamma-miRs were considered: miR-155, miR-146a and miR-21. Our in silico study supports the hypothesis that these inflamma-miRs could modulate some pathways, such as lysine degradation and lengthening of fatty acids which are involved in the modulation of microbiota composition, i.e. prevote...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research