Homologation: A versatile molecular modification strategy to drug discovery.

Homologation: A versatile molecular modification strategy to drug discovery.
Curr Top Med Chem. 2019 Aug 08;:
Authors: Lima LM, Alves MA, do Amaral DN
Abstract
Homologation is a concept introduced by Gerhard in 1853 to describe homologous series into organic chemistry. Since then the concept has been adapted and used in Medicinal Chemistry as one of the most important strategies for molecular modification. The homologation types, their influence on physico-chemical properties and molecular conformation will be presented and discussed. Its application in lead-identification and lead optimization steps, as well as its impact on pharmacodynamics and pharmacokinetic properties will be highlighted from selected examples.
PMID: 31393250 [PubMed - as supplied by publisher]

Source: Current Topics in Medicinal Chemistry - August 7, 2019 Category: Chemistry Authors: Lima LM, Alves MA, do Amaral DN Tags: Curr Top Med Chem Source Type: research