Cancers, Vol. 11, Pages 1143: SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
Cancers, Vol. 11, Pages 1143: SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
Cancers doi: 10.3390/cancers11081143
Authors:
Batham
Lim
Rao
The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelial-to-mesenchymal transition and confer resistance to therapies.
Source: Cancers - Category: Cancer & Oncology Authors: Batham Lim Rao Tags: Review Source Type: research
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