Dissemination of International Clone II Acinetobacter baumannii Strains Coproducing OXA-23 Carbapenemase and 16S rRNA Methylase ArmA in Athens, Greece

Microbial Drug Resistance, Ahead of Print.
Source: Microbial Drug Resistance - Category: Microbiology Authors: Source Type: research

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ConclusionThis study suggested that measurement of MICs, individualized therapy and therapeutic drug-level monitoring should be considered together to achieve the optimal drug exposure. That will provide the best chance of achieving the highest probability of a successful clinical or microbiological response, and avoiding the induced resistance.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 18 October 2019Source: BurnsAuthor(s): Jin Ju Park, Yu Bin Seo, Young Kyun Choi, Dohern Kym, Jacob LeeAbstractInfection is the leading cause of mortality in severe burn patients, benefitting from periodic monitoring of changes in bacterial prevalence and antibiotic resistance trends. This single facility retrospective study evaluated blood culture results for patients hospitalized in the burn intensive care unit (BICU) from January 2012 to December 2017. A total of 969 samples from 420 patients were reviewed. Isolated pathogens were recorded by year and the number of days of hospitalizati...
Source: Burns - Category: Dermatology Source Type: research
Authors: Montravers P, Zappella N, Tran-Dinh A Abstract Introduction: Complicated intra-abdominal infections (cIAIs) are among the most frequent infections, contributing to significant morbidity and healthcare costs. Several medical needs remain unmet, related to the pharmacokinetic capacities of the available drugs and their limited spectrum of activity for targeting multidrug-resistant Gram-negative and Gram-positive bacteria. Eravacycline, a new synthetic fluorocycline, could have useful properties in cIAIs. Areas covered: The antimicrobial activity of eravacycline against the microorganisms most frequently cult...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
In this study, using the mouse model of intraperitoneal (i.p.) mucin-enhanced A. baumannii infection, we characterized the kinetics of bacterial replication and dissemination and the host innate immune responses, as well as their potential contribution to mucin-enhanced bacterial virulence. We found that mucin, either admixed with or separately injected with the challenge bacterial inoculum, was able to enhance the tissue and blood burdens of A. baumannii strains of different virulence. Intraperitoneal injection of A. baumannii-mucin or mucin alone induced a significant but comparable reduction of peritoneal macrophages an...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Bacterial Infections Source Type: research
Publication date: Available online 17 October 2019Source: Microbial PathogenesisAuthor(s): Mandana Ohadi, Hamid Forootanfar, Gholamreza Dehghan-Noudeh, Touba Eslaminejad, Atefeh Ameri, Mojtaba Shakibaie, Mahboubeh Adeli-SardouAbstractLipopeptide biosurfactants (LPBs) are amphiphilic compounds produced by microorganisms exhibiting various biological activities. The main aim of the present study was to assess the in vitro antimicrobial, anti-biofilm, and cytotoxic effects of LPB produced by Acinetobacter junii (AjL). We determined AjL minimum inhibitory concentration (MIC) against both Gram-positive and Gram-negative bacteri...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 15 October 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Rida Sajjad, Sajjad Ahmad, Syed Sikander AzamAbstractGlobally, antibiotic-resistant and tolerated bacterial isolates of Acinetobacter species are imposing high financial cost on health care systems and as such, molecular targets with promising immune protection could provide substantive benefits to human healthcare. Here, we performed an in silico based proteome-wide screening for antigenic B-cell derived T-cell epitopes and their following use to design a multi-epitope peptide vaccine that can effectively engage...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Between January 2015 and July 2017, we investigated the frequency of carbapenem resistant Acinetobacter baumannii (CRAB) and carbapenem resistant Pseudomonas aeruginosa (CRPA) at the Mulago Hospital intensive car...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
In this study we demonstrate that the supernatant from novel environmental isolates of Delftia spp. have antimicrobial activity. We characterized the active fraction and identified delftibactin A as a compound with antimicrobial activity. Delftibactin A exhibits potent antimicrobial activity against Gram positive multi drug resistant (MDR) bacteria like Methicillin-resistant Staphylococcus aureus (MRSA), and Vancomycin resistant Enterococcus (VRE), and also against the Gram negative pathogens Acinetobacter baumannii and Klebsiella pneumoniae. We discovered that the production of delftibactin A is greatly influenced by temp...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Abstract Baeyer-Villiger monooxygenases (BVMOs) are remarkable biocatalysts but due to their low stability, their application in industry is hampered. Thus, there is a high demand to expand the diversity and increase the stability of this class of enzyme. Starting from a known thermostable BVMO sequence from Thermocrispum municipale (TmCHMO), we identified a novel BVMO from Amycolaptosis thermoflava (BVMOFlava) that was successfully expressed in Escherichia coli BL21(DE3). We investigated the activity and stability of the purified enzyme and assigned the substrate profile for structurally different cyclohexanones ...
Source: Chembiochem - Category: Biochemistry Authors: Tags: Chembiochem Source Type: research
We examined the in vitro activity of meropenem + WCK 4234 (4 or 8 μg/ml) against Gram-negative pathogens from New York City. Three groups were analyzed: a contemporary collection of isolates, a collection of known carbapenem-resistant isolates, and a collection of isolates with defined resistance mechanisms. From the contemporary collection, 1) all Enterobacteriaceae were susceptible to meropenem + WCK 4234, 2) susceptibility rates for Acinetobacter baumannii to meropenem alone were 56.5%, with WCK 4234 4 μg/ml 82.6%, and with WCK 4234 8 μg/ml 95.7%, and 3) WCK 4234 had modest effect on susceptibility for P. aerug...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
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