Therapy with ticagrelor for ST-elevated acute coronary syndrome accompanied by diabetes mellitus.

Therapy with ticagrelor for ST-elevated acute coronary syndrome accompanied by diabetes mellitus. Eur Rev Med Pharmacol Sci. 2019 Aug;23(3 Suppl):312-318 Authors: Liu Y, Ding LY, Li XZ Abstract OBJECTIVE: To investigate the protective effect of ticagrelor on the myocardium of patients with ST-elevated acute coronary syndrome accompanied by diabetes mellitus. PATIENTS AND METHODS: 210 patients with diabetes mellitus receiving emergency percutaneous coronary intervention (PCI) due to ST-elevated acute coronary syndrome from December 2014 to June 2018 in the Hospital were selected and randomly divided into ticagrelor group and clopidogrel group. The myocardial microcirculation perfusion was evaluated via ST-segment elevation resolution (STR) in electrocardiogram (ECG) and myocardial blush grade (MBG). Myocardial necrosis markers, including creatine kinase (CK), CK-MB, and cardiac troponin I (cTnI), were evaluated. Moreover, the cardiac function was assessed using brain natriuretic peptide (BNP) level and left ventricular ejection fraction (LVEF). Finally, patients were followed up for one month on average, and the adverse cardiovascular and bleeding events were recorded. RESULTS: The results showed that CK, CK-MB, cTnI, and BNP levels in ticagrelor group were lower than those in clopidogrel group, and the differences were statistically significant (p
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

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Source: The Lancet - Category: General Medicine Source Type: research
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Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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Source: Current Cardiology Reports - Category: Cardiology Source Type: research
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Source: American Heart Journal - Category: Cardiology Source Type: research
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Source: American Heart Journal - Category: Cardiology Source Type: research
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Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: Diabetes Therapy - Category: Endocrinology Source Type: research
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Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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