The impact of skeletal muscle abnormalities on tolerance to adjuvant chemotherapy and radiation and outcome in patients with endometrial cancer

We examined the effect of low SMI and SMD on treatment tolerance and survival outcomes in patients with endometrial cancer receiving pelvic radiation.MethodsStage IB ‐IVA patients with endometrial cancer treated at one institution between 2007 and 2017 were reviewed. All patients received hysterectomy and pelvic radiation. SMI was based on the cross‐sectional area of skeletal muscle at the L3 vertebral body. SMD was expressed as the mean radiation attenuatio n in Hounsfield units (HUs) at the same vertebral level.ResultsSixty ‐four patients met criteria for analysis. Forty‐four per cent had low SMI (
Source: Journal of Medical Imaging and Radiation Oncology - Category: Radiology Authors: Tags: Radiation Oncology —Original Article Source Type: research

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ConclusionsNeoadjuvant chemoradiation therapy effectively downstages the majority of locally advanced type II endometrial cancers, thereby increasing the likelihood of achieving complete resection with negative margins.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 27 February 2019Source: Gynecologic Oncology ReportsAuthor(s): Ikumi Kuno, Hiroshi Yoshida, Takashi Kohno, Atsushi Ochiai, Tomoyasu KatoAbstractUterine malignant lymphoma is rare and its association with secondary cancer has not been fully described. Here, we report a rare case of endometrial cancer arising after 1 year of complete remission of uterine diffuse large B-cell lymphoma (DLBCL). An 88-year-old woman was referred to us for abnormal genital bleeding and was diagnosed with uterine DLBCL. She underwent chemotherapy comprising rituximab with cyclophosphamide, doxorubicin, vincris...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: July–August 2018Source: Journal of Minimally Invasive Gynecology, Volume 25, Issue 5Author(s): Valerio Gallotta, Marco D'Indinosante, Camilla Nero, Maria Teresa Giudice, Carmine Conte, Claudio Lodoli, Gian Franco Zannoni, Anna Fagotti, Giovanni ScambiaAbstractStudy ObjectiveTo demonstrate management of a rare case of an isolated intraparenchymal splenic metastasis of endometrial cancer with robotic-assisted surgery.DesignCase report (Canadian Task Force Classification III).SettingA 55-year-old patient with a history of endometrial cancer was found to have a splenic lesion on a follow-up examination....
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Jeanine N. Staples, Lisa Rauh, M. Sean Peach, William D. Baker, Susan C. ModesittAbstractObjectivesThe study objectives were to describe outcomes of obese patients with early endometrial cancer following primary non-surgical treatment, assess predictors of response, and estimate the increased surgical risk for these women.MethodsRetrospective chart review identified women with early stage endometrial cancer at a single institution with BMI ≥ 30 kg/m2 who did not undergo surgery as primary treatment modality due to obesity and me...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: July–August 2018Source: Journal of Minimally Invasive Gynecology, Volume 25, Issue 5Author(s): Valerio Gallotta, Marco D'Indinosante, Camilla Nero, Maria Teresa Giudice, Carmine Conte, Claudio Lodoli, Gian Franco Zannoni, Anna Fagotti, Giovanni ScambiaAbstractStudy ObjectiveTo demonstrate management of a rare case of an isolated intraparenchymal splenic metastasis of endometrial cancer with robotic-assisted surgery.DesignCase report (Canadian Task Force Classification III).SettingA 55-year-old patient with a history of endometrial cancer was found to have a splenic lesion on a follow-up examination....
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Jeanine N. Staples, Lisa Rauh, M. Sean Peach, William D. Baker, Susan C. ModesittAbstractObjectivesThe study objectives were to describe outcomes of obese patients with early endometrial cancer following primary non-surgical treatment, assess predictors of response, and estimate the increased surgical risk for these women.MethodsRetrospective chart review identified women with early stage endometrial cancer at a single institution with BMI ≥ 30 kg/m2 who did not undergo surgery as primary treatment modality due to obesity and me...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Abstract OBJECTIVE: To assess the impact of adjuvant treatment, sociodemographic and tumor factors on the survival of patients with non-metastatic clear cell endometrial carcinoma (CCC). METHODS: 4298 patients treated from 1998 to 2011 with Stage I-IVA CCC were identified within the National Cancer Database. FIGO 2009 staging system was used. Adjuvant groups included: hysterectomy (HYS); HYS+vaginal brachytherapy (VBT); HYS+chemotherapy (CT); HYS+external beam radiation therapy (EBRT); HYS+CT+EBRT; and HYS+CT+VBT. Univariable (UVA) and multivariable (MVA) frailty survival analyses were performed. RESULTS...
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
Conclusions This case shows a successful robotic management of recurrent endometrial cancer.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusions: The high-risk group had a significantly poorer survival rate than the low-risk group, and distant metastasis was the main pattern of recurrence, thus indicating that further adjuvant chemotherapy should be considered in high-risk patients.
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
Objectives: Recent data have shown high rates of clinical and pathologic responses to neoadjuvant radiation therapy for locally advanced endometrial cancer. There are limited data on the surgical outcomes of these patients in the era of modern radiation and surgical techniques. We sought to characterize surgical outcomes after extrafascial hysterectomy in this population. Methods: Patients with endometrial cancer of all histologies clinically involving the cervix or parametria treated with neoadjuvant brachytherapy followed by extrafascial hysterectomy from 1999 to 2014 were identified. Patient charts were reviewed for da...
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research
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