Whole-Body CT for Children After Trauma: Undefined Efficacy With Clear Cancer Risks

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Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Letters to the Editor Source Type: research

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Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01447K, CommunicationKangyao Zhang, Shuzhen Lv, Dianping Tang A new enzyme-free and portable photoelectrochemical sensing method based on a homemade three dimensional (3D) printing device was developed for accurate monitoring of low-abundance cancer biomarker (carcinoembryonic antigen, CEA, was... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Authors: Shan Q, Li Z, Lin J, Wang Z, Wang H Abstract OBJECTIVE: Our study was performed to clarify which patients with metastatic extensive-stage small cell lung cancer (ES-SCLC) could gain survival benefit from local radiotherapy. PATIENTS AND METHODS: A chi-square test was used to compare baseline characteristics of different groups. Kaplan-Meier method was applied to analyzing the survival difference. The prognostic factors for cancer-specific survival (CSS) in patients receiving radiotherapy were analyzed by the Cox proportional hazard model. According to the above information, we established a prognostic ...
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research
Authors: Liu J, Li Y, Yang D, Yang C, Mao L Abstract In recent years, with the westernization of lifestyle, reduced physical activity and increased prostate-specific antigen (PSA) testing, the incidence of prostate cancer (PCa) has risen significantly in developing countries. Currently, PSA is the only PCa biomarker applied clinically, but it does not perform well in the early diagnosis and distinguishing between benign prostatic hyperplasia and prostate cancer. With the advances in deep sequencing technology, a series of new PCa biomarkers have been recently proposed to improve the diagnostic value of PSA, such as...
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research
ConclusionsAll stage N3b patients with AGC should not be considered equivalent. A significant difference in survival was observed between stage N3b1 and N3b2 patients after radical surgery, while the survival of stage N3b2 patients was similar to that of patients who undergo palliative surgery. We recommend re-classifying stage T2 –3N3b1 as TNM stage IIIB, stage T4N3b1 as stage IIIC, and T2–4N3b2 as stage IV.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
Authors: Zou LQ, Yang X, Li YD, Zhu ZF Abstract Introduction: The poor prognosis for patients with esophageal cancer (EC) requires evolving current treatment regimens. Immune checkpoint inhibitors show clinical efficacy and a great safety profile in multiple tumors. And the monoclonal antibodies that target programmed death receptor-1/programmed death receptor ligand-1 or the cytotoxic T lymphocyte antigen-4 pathway has shown potential curable effect of EC. Areas covered: This review article covers the prognostic significance of immune checkpoint expression, the accumulating current clinical studies of checkpoint i...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Authors: Alhouayek M, Boldrup L, Fowler CJ Abstract Little is known about the endocannabinoid (eCB) system in squamous cell carcinoma of the oral tongue (SCCOT). Here we have investigated, at the mRNA level, expression of genes coding for the components of the eCB system in tumour and non-malignant samples from SCCOT patients. Expression of NAPEPLD and PLA2G4E, coding for eCB anabolic enzymes, was higher in the tumour tissue than in non-malignant tissue. Among genes coding for eCB catabolic enzymes, expression of MGLL was lower in tumour tissue while PTGS2 was increased. It is concluded that the eCB system may be d...
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
Abstract The technology of "sequential windowed acquisition of all theoretical fragment ion spectra," known as SWATH-MS, is rapidly gaining popularity as a next generation proteomics technology for comprehensive proteome quantitation. In this chapter, we describe the use of SWATH-MS as a label-free quantitative technique in a proteomics study to identify novel serological biomarker for colorectal cancer. We compared the secreted glycoprotein profiles (glyco-secretomes) enriched from the colon adenocarcinoma cell line HCT-116 and its metastatic derivative, E1, and observed that laminin β-1 (LAMB1) wa...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Abstract The neural crest is a transient embryonic tissue that originates from the border of the neural plate prior to delamination and migration throughout the developing embryo, where it contributes to a wide range of different tissues. Defects in neural crest development have been implicated in a variety of different disorders (neurocristopathies) including cancers, neuropathies, craniofacial malformations, and pigment disorders. The differentiation of human pluripotent stem cells (hPSCs) into an in vitro counterpart to neural crest cells holds huge potential for the study of neural crest development, as well a...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Contributors : Cigdem Gungormez ; Emine Teker ; Sema Atmanoglu ; Ersin BorazanSeries Type : Expression profiling by arrayOrganism : Homo sapiens ; synthetic constructThe aim of this study is to analyze microRNA expression profile, and through bioinformatic analyses determine the cellular processes of potential target genes and understand their molecular mechanism in stage IIIA colon cancer patients. The microRNA expression profiles of both normal and tumor tissues of seven patients were analyzed using the Affymetrix microarray system.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens synthetic construct Source Type: research
Contributors : Imed E Gallouzi ; Sergio Di-Marco ; Brenda J SanchezSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHere we show that, when compared to control mice, muscle specific HuR knockout (muHuR-KO) animals have higher exercise endurance that is associated with a significant increase in oxygen consumption and carbon dioxide production. Histological analysis demonstrates that the absence of HuR significantly enhances the proportion of oxidative type I fibers in several skeletal muscles, showing that under normal conditions, HuR promotes the formation of glycolytic type II fibers....
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
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