Medical News Today: Could activating these immune cells protect against MS?

New research in mice suggests that stimulating a particular group of immune cells could counteract the autoimmune reaction in multiple sclerosis.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news

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Following publication the authors informed the Journal that  the published version of this article contained a mistake. All occurrences of pg/μl found in the original article should be changed to pg/L. The original article has been corrected. The correction has no impact on the conclusions drawn in the manuscript.
Source: Neurological Sciences - Category: Neurology Source Type: research
AbstractGadolinium-based contrast agents (GBCAs) increase lesion detection and improve disease characterization for many cerebral pathologies investigated with MRI. These agents, introduced in the late 1980s, are in wide use today. However, some non-ionic linear GBCAs have been associated with the development of nephrogenic systemic fibrosis in patients with kidney failure. Gadolinium deposition has also been found in deep brain structures, although it is of unclear clinical relevance. Hence, new guidelines from the International Society for Magnetic Resonance in Medicine advocate cautious use of GBCA in clinical and resea...
Source: Insights into Imaging - Category: Radiology Source Type: research
ConclusionsThe base-case analysis shows that treatment of RRMS with cladribine tablets is cost effective versus alemtuzumab and fingolimod in HDA patients, and cost effective versus natalizumab in RES patients, at a threshold of €50,000. Driven by the lower costs, cladribine tablets were cost effective (dominant) in all base-case analyses. However, given that outcomes are based on indirect comparisons and post hoc subgroup analysis, as well as the uncertainty surrounding the outcomes, the results presented in this paper s hould be interpreted with caution.
Source: Applied Health Economics and Health Policy - Category: Health Management Source Type: research
Multiple Sclerosis (MS) is a neurodegenerative disease associated with cognition and balance impairments, which can lead to accidental falls. Postural control requires cognitive resources. This interaction is quantifiable by using the dual-task paradigm. The cognitive-postural interference (CPI) is commonly evaluated through an assessment of the dual-task cost (DTC). However, heterogeneous methodology for the assessment of DTC creates ambiguity and complicates comparison of results documenting a CPI. The aim of this review was to summarise literature related to process, results and effects of CPI in MS patients. The Pris...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Tracking sNfL levels over time corresponds to multiple sclerosis disease course in a longitudinal study, but use of the blood biomarker for individual prognosis remains unclear.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Authors: Chisari CG, Toscano S, D'Amico E, Lo Fermo S, Zanghì A, Arena S, Zappia M, Patti F Abstract Introduction: In the last 20 years the armamentarium for multiple sclerosis (MS) treatment has been enriched from an increasingly wider variety of new drugs in order to reach a better control of the disease with a better patient compliance. Areas covered: With this great variety of therapeutic options, physicians may face new and major challenges. The huge amount of data from pilot studies and real-life settings showed that the first line therapies have a better safety profile. On the other hand, the risks as...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
European researchers have identified a visual sign on 3-tesla MR images that...Read more on AuntMinnie.comRelated Reading: 7T MRI and 3D printing uncover signs of severe MS 7T MRI shows path to MS progression Contrast not needed for follow-up MRI on MS patients MRI shows drug slows brain atrophy in MS patients MRI links iron in the brain to multiple sclerosis
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
The persistent the inflammatory condition in multiple sclerosis (MS) may due to the aberrant regulation of the elimination of the pathogenic autoreactive lymphocytes through apoptosis. Survivin, encoded by the...
Source: BMC Immunology - Category: Allergy & Immunology Authors: Tags: Research article Source Type: research
Venous percutaneous transluminal angioplasty (vPTA) in patients with multiple sclerosis (MS) and chronic cerebrospinal venous insufficiency (CCSVI) have shown contradictory results. Aim of the study is to evaluate the efficacy of the procedure in a randomized wait list control study.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Clinical Research, Basic Science Source Type: research
GDF-15, a member of the transforming growth factor beta superfamily, regulates inflammatory and apoptotic pathways in various diseases, such as heart failure, kidney dysfunction, and cancer. We aimed to clarify potentially confounding variables affecting GDF-15 and demonstrate its utility as a mitochondrial biomarker using serum samples from 15 patients with mitochondrial diseases (MD), 15 patients with limbic encephalitis (LE), 10 patients with multiple sclerosis/neuromyelitis optica spectrum disorders (MS/NMOSD), and 19 patients with amyotrophic lateral sclerosis (ALS).
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
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