Long Term Renal Function in Asian HIV-1 Infected Adults Receiving Tenofovir Disoproxil Fumarate Without Protease Inhibitors

Tenofovir disoproxil fumarate (TDF) is a nucleotide reverse transcriptase inhibitor (NRTIs) widely used as part of the initial antiretroviral therapy (ART) for HIV-1 infected patients in low- and high- income countries following the current World Health Organization (WHO) recommendations.1 TDF is also used in combination with emtricitabine for pre-exposure prophylaxis of HIV infection1 and, in monotherapy, for the treatment of hepatitis B virus infection.2 The availability of highly potent antiviral therapy has dramatically improved the survival of HIV infected patients but chronic kidney disease (CKD) has been recognized as one of the major HIV infection comorbidities.

Source: Journal of Infection - August 7, 2019 Category: Infectious Diseases Authors: Geoffroy LIEGEON, Linda HARRISON, Anouar NECHBA, Guttiga HALUE, Sukit BANCHONGKIT, Ampaipith NILMANAT, Naruepon YUTTHAKASEMSUNT, Panita PATHIPVANICH, Suchart THONGPAEN, Rittha LERTKOONALAK, Thomas ALTHAUS, Marc LALLEMANT, Jean-Yves MARY, Gonzague JOURDAIN Source Type: research