Therapeutic effects of hydro-alcoholic extract of Achillea wilhelmsii C. Koch on indomethacin-induced gastric ulcer in rats: a proteomic and metabolomic approach

Gastric ulcer is one of the most prevalent diseases worldwide. In Iranian folk medicine, Achillea wilhelmsii (AW) is used as a treatment for gastric ulcer. Previous reports also mentioned Antiulcerogenic properti...
Source: BMC Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Tags: Research article Source Type: research

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ConclusionsThe extract showed anti-ulcer potential and is ready for clinical evaluation.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe extract showed anti-ulcer potential and is ready for clinical evaluation.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: The expression of lncRNAs is abnormal in the kidney of LN. LncRNA RP11-2B6.2 is a novel positive regulator of IFN-I pathway through epigenetic inhibition of SOCS1, which provides a new therapeutic target to alleviate over-activated IFN-I signaling in LN. Introduction Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by the occurrence of a wide range of autoantibodies and organ damage and predominantly affects women at childbearing age (1, 2). Lupus nephritis (LN) is considered one of the most prevalent and serious complications of SLE with high morbidity and mortali...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Wu X, Huang Q, Xu N, Cai J, Luo D, Zhang Q, Su Z, Gao C, Liu Y Abstract Acrostichum aureum Linn., a medicinal pteridophyte growing in mangrove forests and coastal regions of tropical and subtropical areas worldwide, has been proved to possess various biological effects. However, the protective effect of Acrostichum aureum Linn. against gastric ulcer still remains unidentified. Therefore, the gastroprotective effect of the water extract of Acrostichum aureum Linn. (WEAC) was investigated in ethanol-induced gastric injury model. According to our results, pretreatment with WEAC (100, 200, and 400 mg/kg) could...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 15 January 2019Source: Food BioscienceAuthor(s): Hojeong Jeong, Dongyeop Kim, Hyo Jin Song, Soohyung Lee, Mihyung Kim, Keuk-Jun Kim, Gi Dong HanAbstractFermented barley bran (FBB) using Bacillus spp. is the main ingredient of sigumjang, a traditional fermented food in South Korea. The aim of this study was to evaluate the gastro-protective effects of β-glucan-enriched FBB extracts in an experimental mouse model of the EtOH-induced gastric ulcer. The gastro-protective activity of FBB was determined using histopathological inspection, level of EtOH absorption from the gastrointestinal-...
Source: Food Bioscience - Category: Food Science Source Type: research
Conclusion: These findings indicated that L. reuteri F-9-35 pretreatment can attenuate ethanol-induced gastric injury in rats by inhibiting oxidative stress and inflammatory response. Together, L. reuteri F-9-35 has potential preventive efficacy on gastric ulcer. PMID: 30574053 [PubMed]
Source: Food and Nutrition Research - Category: Nutrition Authors: Tags: Food Nutr Res Source Type: research
Conclusion: Biliary reflux and alcohol consumption, but not Helicobacter pylori infection or gastrotoxic drug, seem to be the most important predictors for ulcer recurrence in patients with gastric surgery for peptic ulcer after more than 15 years. PMID: 30524477 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
AbstractThe aim of this study was to elucidate the gastroprotective activity and possible mechanism of involvement of araloside A (ARA) against ethanol- and aspirin-induced gastric ulcer in mice. The experimental mice were randomly divided into control, model, omeprazole (20  mg/kg, orally) and ARA (10, 20 and 40 mg/kg, orally). Gastric ulcer in mice was induced by intragastric administration of 80% ethanol (10 mL/kg) containing 15 mg/mL aspirin 4 h after drug administration on day 7. The results indicated that ARA could significantly raise gastric juice volume and acidity; ameliorate gastric mucos...
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 22 October 2018Source: Toxicology ReportsAuthor(s): Subrata Ghosh, Anirban Roy, Anup Singhania, Somnath Chatterjee, Snehasikta Swarnakar, Daisuke Fujita, Anirban BandyopadhyayAbstractPC, PCM, PCS, and PCMS are our designed &synthesized ~8 nm PAMAM dendrimer (P) -based organic supramolecular systems, for example, PCMS has 32 molecular motors (M), 4 pH sensors (S) and 2 multi-level molecular electronic switches (C). We have reported earlier following a preliminary in-vitro test that the synthesized PCMS can selectively target cancer cell nucleotides if triggered wirelessly...
Source: Toxicology Reports - Category: Toxicology Source Type: research
The U.S. Food and Drug Administration permitted marketing of Hemospray, a new device used to help control certain types of bleeding in the gastrointestinal (GI) tract.“The device provides an additional, non-surgical option for treating upper and lower GI bleeding in certain patients, and may help reduce the risk of death from a GI bleed for many patients,” said Binita Ashar, M.D., director, division of surgical devices, in the FDA’s Center for Devices and R adiological Health.GI bleeding can occur in the upper GI tract (esophagus, stomach or small intestine) or the lower GI tract (colon and rectum). Cause...
Source: Medical Hemostat - Category: Medical Devices Authors: Source Type: blogs
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