Small cell and large cell neuroendocrine carcinoma of the larynx: A comparative analysis

Neuroendocrine tumors of the larynx constitute a rare and morphologically heterogeneous group of tumors. They are characterized by the presence of neurosecretory granules and share a characteristic immune profile. According to the 2017 WHO proposed classification, the poorly differentiated neuroendocrine carcinomas (NECs) comprise the poorly differentiated neuroendocrine carcinomas of a small cell-type (SCNEC) and a large cell-type (LCNEC) (Fig. 1). The other two tumors of epithelial origin are the well differentiated neuroendocrine carcinoma and the moderately differentiated neuroendocrine carcinoma [1].

Source: Cancer Treatment Reviews - August 7, 2019 Category: Cancer & Oncology Authors: Primo ž Strojan, Juan C. Hernandez-Prera, Jonathan J. Beitler, Avraham Eisbruch, Nabil F. Saba, William M. Mendenhall, Carlos Suarez Nieto, Robert Smee, Alessandra Rinaldo, Alfio Ferlito Tags: Systematic or Meta-analysis Studies Source Type: research