Enhancer Features that Drive Formation of Transcriptional Condensates

Shrinivas et  al. demonstrate that specific types of motif compositions encoded in DNA drive localized formation of transcriptional condensates. These findings explain how phase separation can occur at specific genomic locations and shed light on why only some genomic loci become highly active enhancers.

Source: Molecular Cell - August 7, 2019 Category: Cytology Authors: Krishna Shrinivas, Benjamin R. Sabari, Eliot L. Coffey, Isaac A. Klein, Ann Boija, Alicia V. Zamudio, Jurian Schuijers, Nancy M. Hannett, Phillip A. Sharp, Richard A. Young, Arup K. Chakraborty Tags: Article Source Type: research