Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

This work illustrates the heterogeneity of liver non-parenchymal cells (NPCs) and their reprogramming during NASH pathogenesis. Using single-cell RNA-sequencing analysis, the authors mapped the landscape of the intrahepatic ligand-receptor signaling network and revealed two fundamental aspects of HSC biology: stellakine secretion and contractile response to vasoactive hormones. Hepatic vascular dysfunction and emergence of Trem2+ NASH-associated macrophages (NAMs) are two conserved features of mouse and human NASH.

Source: Molecular Cell - August 7, 2019 Category: Cytology Authors: Xuelian Xiong, Henry Kuang, Sahar Ansari, Tongyu Liu, Jianke Gong, Shuai Wang, Xu-Yun Zhao, Yewei Ji, Chuan Li, Liang Guo, Linkang Zhou, Zhimin Chen, Paola Leon-Mimila, Meng Ting Chung, Katsuo Kurabayashi, Judy Opp, Francisco Campos-P érez, Hugo Villamil Tags: Resource Source Type: research