Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P2 Synthesis

Nishimura et  al. show that the Osh lipid exchange proteins are required for PI(4,5)P2 synthesis, a key regulator of global plasma membrane organization and function. The Osh proteins form a unique membrane lipid environment with unsaturated phosphatidylserine and sterols that specifies PIP 5-kinase activity at the plasma membrane.

Source: Molecular Cell - August 7, 2019 Category: Cytology Authors: Taki Nishimura, Michael Gecht, Roberto Covino, Gerhard Hummer, Michal A. Surma, Christian Klose, Hiroyuki Arai, Nozomu Kono, Christopher J. Stefan Tags: Article Source Type: research